Tbio WNT8A Protein Wnt-8a

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9H1J5
• Q96S51

Gene Name

• WNT8A

Ensembl ID

• ENST00000361560
• ENSP00000354726
• ENSG00000061492
• ENST00000398754
• ENSP00000381739

Symbol

• WNT8D
• WNT8D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.67
PubMedID	0.62
cell line	0.57
pathway	0.52
biological process	0.5

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-8a

DTO Classes

Protein / Signaling / Protein Wnt-8a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.95   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 192   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.95   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0