Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
- ENST00000361560
- ENSP00000354726
- ENSG00000061492
- ENST00000398754
- ENSP00000381739
- WNT8D
- WNT8D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue | 0.67 | ||
PubMedID | 0.62 | ||
cell line | 0.57 | ||
pathway | 0.52 | ||
biological process | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.95 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 192 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.95 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 192 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (151)
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (73)
Reactome (8)
KEGG (13)
PathwayCommons (28)
WikiPathways (24)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | Disassembly of the destruction complex and recruitment of AXIN to the membrane | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
Disassembly of the destruction complex and recruitment of AXIN to the membrane | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (3)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | WormBase | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 3 | 0 | 1.1 | 96.4 | |||||
balding measurement | 1 | 1 | 1 | 31.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 20.5 | |||||
mathematical ability | 1 | 1 | 1 | 20.5 | |||||
QT interval | 1 | 1 | 1 | 6.2 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 96.4 | |||||
balding measurement | 1 | 31.7 | |||||
self reported educational attainment | 1 | 20.5 | |||||
mathematical ability | 1 | 20.5 | |||||
QT interval | 1 | 6.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Wnt family member 8A | VGNC:13614 | 471645 | |||||
Macaque | Wnt family member 8A | 713764 | ||||||
Mouse | MGI:107924 | 20890 | ||||||
Rat | RGD:1306312 | 291678 | ||||||
Dog | Wnt family member 8A | VGNC:48429 | 100855884 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Wnt family member 8A | |||||
Macaque | Wnt family member 8A | |||||
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 8A | |||||
Publication Statistics
PubMed Score 64.95
PubMed score by year
PubTator Score 11.72
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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