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Tbio
WNT7A
Protein Wnt-7a

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity). This gene is a member of the WNT gene f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285018
  • ENSP00000285018
  • ENSG00000154764
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
0.72
phenotype
0.69
PubMedID
0.69
gene perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.6   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.6   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (164)
WNT7B
Tbio
Novelty:  0.00684526
p_int:  0.99999993
p_ni:  7e-9
p_wrong:  6.2e-8
Score:  0.923
Data Source:  BioPlex,STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
p_int:  0.999997711
p_ni:  0.000002288
p_wrong:  1e-9
Score:  0.959
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999992548
p_ni:  0.000007452
Data Source:  BioPlex
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.99996341
p_ni:  0.00003659
Score:  0.22
Data Source:  BioPlex,STRINGDB
WLS
Tbio
Novelty:  0.01459149
p_int:  0.999902687
p_ni:  0.000097313
Score:  0.959
Data Source:  BioPlex,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.995141079
p_ni:  0.004858921
Data Source:  BioPlex
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.994287707
p_ni:  0.005712293
Score:  0.228
Data Source:  BioPlex,STRINGDB
FBLN1
Tbio
Novelty:  0.00796703
p_int:  0.993948462
p_ni:  0.006051538
Score:  0.178
Data Source:  BioPlex,STRINGDB
CRELD2
Tbio
Novelty:  0.09438775
p_int:  0.992352248
p_ni:  0.007647567
p_wrong:  1.85e-7
Score:  0.167
Data Source:  BioPlex,STRINGDB
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.991755658
p_ni:  0.008244342
Data Source:  BioPlex
Pathways (59)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter integrity
20
5
20
86.5
neuroimaging measurement
34
6
34
85.3
forced expiratory volume
1
1
1
57.8
glomerular filtration rate
3
2
3
56.1
schizophrenia
1
1
0
1.1
53.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter integrity
20
86.5
neuroimaging measurement
34
85.3
forced expiratory volume
1
57.8
glomerular filtration rate
3
56.1
schizophrenia
0
1.1
53.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Wnt family member 7A
693419
Mouse
MGI:98961
22421
Rat
RGD:69079
114850
Dog
Wnt family member 7A
VGNC:48428
607180
Horse
Wnt family member 7A
VGNC:25048
100055450
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Wnt family member 7A
Mouse
Rat
Dog
Wnt family member 7A
Horse
Wnt family member 7A
Publication Statistics
PubMed Score 254.60
PubMed score by year
PubTator Score 94.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title