Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
- ENST00000310594
- ENSP00000308887
- ENSG00000111186
- ENST00000397196
- ENSP00000380379
- ENST00000537031
- ENSP00000439312
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.85 | ||
gene perturbation | 0.71 | ||
pathway | 0.67 | ||
transcription factor | 0.57 | ||
biological process | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.9 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 230 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.9 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 230 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (131)
WNT5A
Novelty: 0.00125563
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.923
Data Source: BioPlex,STRINGDB
KLRG2
Novelty: 1.19446694
p_int: 0.999659399
p_ni: 0.00000964
p_wrong: 0.000330961
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (59)
Reactome (5)
KEGG (14)
PathwayCommons (30)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | PCP/CE pathway | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by WNT | ||||
Reactome | WNT ligand biogenesis and trafficking | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
PCP/CE pathway | ||||
Signal Transduction | ||||
Signaling by WNT | ||||
WNT ligand biogenesis and trafficking | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (2)
Components (9)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 7 | 15 | 98.4 | |||||
red blood cell distribution width | 2 | 2 | 2 | 57.2 | |||||
bone density | 2 | 2 | 2 | 57 | |||||
mean corpuscular volume | 1 | 1 | 1 | 3.9 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 15 | 98.4 | |||||
red blood cell distribution width | 2 | 57.2 | |||||
bone density | 2 | 57 | |||||
mean corpuscular volume | 1 | 3.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Wnt family member 5B | VGNC:10084 | 467191 | |||||
Mouse | MGI:98959 | 22419 | ||||||
Rat | RGD:628850 | 282582 | ||||||
Dog | Wnt family member 5B | VGNC:48426 | 486756 | |||||
Horse | Wnt family member 5B | VGNC:25047 | 100056017 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Wnt family member 5B | |||||
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 5B | |||||
Horse | Wnt family member 5B | |||||
Publication Statistics
PubMed Score 93.90
PubMed score by year
PubTator Score 31.42
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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