Tbio WNT5A Protein Wnt-5a

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P41221
• A8K4A4
• Q6P278

Gene Name

• WNT5A

Ensembl ID

• ENST00000264634
• ENSP00000264634
• ENSG00000114251
• ENST00000474267
• ENSP00000417310
• ENST00000497027
• ENSP00000420104

Symbol

• hWNT5A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
PubMedID	1
biological term	0.98
microRNA	0.89
gene perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-5a

DTO Classes

Protein / Signaling / Protein Wnt-5a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1103.51   (req: < 5)

Gene RIFs: 422   (req: <= 3)

Antibodies: 514   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1103.51   (req: >= 5)

Gene RIFs: 422   (req: > 3)

Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 149

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0