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Tbio
WNT10B
Protein Wnt-10b

Protein Summary
Description
Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 1 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301061
  • ENSP00000301061
  • ENSG00000169884
  • ENST00000407467
  • ENSP00000384691

Symbol
  • WNT12
  • SHFM6
  • STHAG8
  • WNT-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
pathway
0.72
PubMedID
0.69
small molecule perturbation
0.64
tissue
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.71   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.71   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (130)
JMJD8
Tbio
Novelty:  0.31175159
p_int:  0.99918944
p_ni:  0.000810547
p_wrong:  1.3e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.950401574
p_ni:  0.049598426
Score:  0.163
Data Source:  BioPlex,STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
p_int:  0.924745703
p_ni:  0.075254297
Score:  0.287
Data Source:  BioPlex,STRINGDB
COL6A2
Tbio
Novelty:  0.01275082
p_int:  0.903460457
p_ni:  0.096539543
Score:  0.205
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.78744615
p_ni:  0.212553849
Score:  0.902
Data Source:  BioPlex,STRINGDB
FZD1
Tchem
Family:  GPCR
Novelty:  0.01097201
Score:  0.974
Data Source:  STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
Score:  0.967
Data Source:  STRINGDB
FZD4
Tchem
Family:  GPCR
Novelty:  0.00577957
Score:  0.966
Data Source:  STRINGDB
FZD9
Tbio
Family:  GPCR
Novelty:  0.01414546
Score:  0.964
Data Source:  STRINGDB
FZD6
Tbio
Family:  GPCR
Novelty:  0.01425136
Score:  0.962
Data Source:  STRINGDB
Pathways (61)
Class B/2 (Secretin family receptors) (R-HSA-373080)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
Developmental Biology
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
Developmental Biology
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
16
99.2
cognitive function measurement
3
2
3
86.2
intelligence
6
5
4
6.4
82.7
self reported educational attainment
4
2
4
6.1
79.3
mathematical ability
2
2
2
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
16
99.2
cognitive function measurement
3
86.2
intelligence
4
6.4
82.7
self reported educational attainment
4
6.1
79.3
mathematical ability
2
74.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 10B
VGNC:13496
451870
Mouse
MGI:108061
22410
Rat
RGD:1304988
315294
Horse
Wnt family member 10B
VGNC:25042
100051649
Pig
Wnt family member 10B
100126276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 10B
Mouse
Rat
Horse
Wnt family member 10B
Pig
Wnt family member 10B
Publication Statistics
PubMed Score 195.71
PubMed score by year
PubTator Score 73.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title