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Tbio
WNT1
Proto-oncogene Wnt-1

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293549
  • ENSP00000293549
  • ENSG00000125084

Symbol
  • INT1
  • INT1
  • OI15
  • BMND16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.92
pathway
0.71
cellular component
0.69
transcription factor binding site profile
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 778.05   (req: < 5)
Gene RIFs: 186   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 778.05   (req: >= 5)
Gene RIFs: 186   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (350)
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.879371019
p_ni:  0.120628981
Score:  0.319
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
Score:  0.998
Data Source:  Reactome,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.994
Data Source:  STRINGDB
PORCN
Tchem
Family:  Enzyme
Novelty:  0.00834643
Score:  0.994
Data Source:  STRINGDB
SFRP1
Tchem
Novelty:  0.00285799
Score:  0.991
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.991
Data Source:  STRINGDB
SFRP2
Tbio
Novelty:  0.00454703
Score:  0.989
Data Source:  STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.985
Data Source:  Reactome,STRINGDB
WLS
Tbio
Novelty:  0.01459149
Score:  0.984
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.982
Data Source:  Reactome,STRINGDB
Pathways (77)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Class B/2 (Secretin family receptors)
Reactome
Developmental Biology
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Class B/2 (Secretin family receptors)
Developmental Biology
Disassembly of the destruction complex and recruitment of AXIN to the membrane
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (68)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
16
99.2
cognitive function measurement
3
2
3
86.2
intelligence
6
6
4
6.1
83.3
bone density
3
2
4
75.2
self reported educational attainment
4
1
3
6.1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
16
99.2
cognitive function measurement
3
86.2
intelligence
4
6.1
83.3
bone density
4
75.2
self reported educational attainment
3
6.1
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 1
VGNC:10083
742674
Macaque
Wnt family member 1
709009
Mouse
MGI:98953
22408
Rat
RGD:1597195
24881
Dog
Wnt family member 1
VGNC:48419
486560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 1
Macaque
Wnt family member 1
Mouse
Rat
Dog
Wnt family member 1
Publication Statistics
PubMed Score 778.05
PubMed score by year
PubTator Score 429.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title