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Tchem
WNK3
Serine/threonine-protein kinase WNK3

Protein Summary
Description
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3. This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354646
  • ENSP00000346667
  • ENSG00000196632
  • ENST00000375159
  • ENSP00000364301
  • ENST00000375169
  • ENSP00000364312

Symbol
  • KIAA1566
  • PRKWNK3
  • PRKWNK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
microRNA
0.81
biological process
0.75
protein domain
0.73
histone modification site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.13   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.13   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (43)
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999999744
p_ni:  2.56e-7
Score:  0.718
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.999993944
p_ni:  0.000006056
Score:  0.224
Data Source:  BioPlex,STRINGDB
SCNN1B
Tclin
Family:  IC
Novelty:  0.01281284
Score:  0.941
Data Source:  STRINGDB
SCNN1G
Tclin
Family:  IC
Novelty:  0.00689941
Score:  0.938
Data Source:  STRINGDB
SCNN1A
Tclin
Family:  IC
Novelty:  0.00900102
Score:  0.938
Data Source:  STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
Score:  0.917
Data Source:  STRINGDB
SLC12A2
Tclin
Family:  Transporter
Novelty:  0.0012043
Score:  0.908
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.902
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.9
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

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Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
8
1
1
0
1.1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
8
0
1.1
2.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WNK lysine deficient protein kinase 3
701015
Mouse
MGI:2652875
279561
Rat
RGD:1563131
317420
Cow
WNK lysine deficient protein kinase 3
VGNC:36951
100337119
Xenopus
WNK lysine deficient protein kinase 3
XB-GENE-5757377
448601
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WNK lysine deficient protein kinase 3
Mouse
Rat
Cow
WNK lysine deficient protein kinase 3
Xenopus
WNK lysine deficient protein kinase 3
Publication Statistics
PubMed Score 31.13
PubMed score by year
PubTator Score 16.67
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title