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Tchem
WNK2
Serine/threonine-protein kinase WNK2

Protein Summary
Description
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell sign ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297954
  • ENSP00000297954
  • ENSG00000165238

Symbol
  • KIAA1760
  • PRKWNK2
  • SDCCAG43
  • PRKWNK2
  • NY-CO-43
  • SDCCAG43
  • P/OKcl.13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
ligand (protein) perturbation
0.83
disease perturbation
0.79
PubMedID
0.65
biological process
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.87   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.87   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (41)
SPATA1
Tdark
p_int:  0.999998523
p_ni:  0.000001427
p_wrong:  5e-8
Data Source:  BioPlex
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.999998245
p_ni:  0.000001697
p_wrong:  5.8e-8
Score:  0.224
Data Source:  BioPlex,STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
Score:  0.969
Data Source:  STRINGDB
SCNN1A
Tclin
Family:  IC
Novelty:  0.00900102
Score:  0.943
Data Source:  STRINGDB
SCNN1G
Tclin
Family:  IC
Novelty:  0.00689941
Score:  0.913
Data Source:  STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
Score:  0.907
Data Source:  STRINGDB
SCNN1B
Tclin
Family:  IC
Novelty:  0.01281284
Score:  0.904
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.902
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.9
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
5
85.4
aspartate aminotransferase measurement
2
2
1
9.8
77.6
serum alanine aminotransferase measurement
2
1
1
8.6
69
L lactate dehydrogenase measurement
1
1
1
62.1
self reported educational attainment
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
85.4
aspartate aminotransferase measurement
1
9.8
77.6
serum alanine aminotransferase measurement
1
8.6
69
L lactate dehydrogenase measurement
1
62.1
self reported educational attainment
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WNK lysine deficient protein kinase 2
717275
Mouse
MGI:1922857
75607
Rat
RGD:1307284
306811
Dog
WNK lysine deficient protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14542]
Horse
WNK lysine deficient protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14542]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WNK lysine deficient protein kinase 2
Mouse
Rat
Dog
WNK lysine deficient protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14542]
Horse
WNK lysine deficient protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14542]
Publication Statistics
PubMed Score 18.87
PubMed score by year
PubTator Score 24.30
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title