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Tchem
WNK1
Serine/threonine-protein kinase WNK1

Protein Summary
Description
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). Isoform 3: Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has n ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315939
  • ENSP00000313059
  • ENSG00000060237
  • ENST00000340908
  • ENSP00000341292
  • ENST00000530271
  • ENSP00000433548
  • ENST00000537687
  • ENSP00000444465

Symbol
  • HSN2
  • KDP
  • KIAA0344
  • PRKWNK1
  • KDP
  • PSK
  • p65
  • HSN2
  • HSAN2
  • PRKWNK1
  • PPP1R167
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor binding site profile
0.96
transcription factor perturbation
0.96
kinase
0.87
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.13   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.13   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (82)
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999996704
p_ni:  0.000003296
Score:  0.702
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.999983335
p_ni:  0.000016665
Data Source:  BioPlex
METTL6
Tdark
Family:  Enzyme
Novelty:  0.43606491
p_int:  0.999977392
p_ni:  0.000022608
Score:  0.219
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.997117447
p_ni:  0.002882547
p_wrong:  6e-9
Data Source:  BioPlex
AAMP
Tbio
Novelty:  0.0160792
p_int:  0.983155993
p_ni:  0.016840615
p_wrong:  0.000003392
Score:  0.234
Data Source:  BioPlex,STRINGDB
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.968909769
p_ni:  0.031090228
p_wrong:  3e-9
Data Source:  BioPlex
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.962876825
p_ni:  0.036638463
p_wrong:  0.000484712
Score:  0.177
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.9519511
p_ni:  0.048048414
p_wrong:  4.86e-7
Data Source:  BioPlex
BAG4
Tbio
Novelty:  0.02660607
p_int:  0.946390077
p_ni:  0.049447408
p_wrong:  0.004162515
Data Source:  BioPlex
SERPINB13
Tbio
Novelty:  0.01753451
p_int:  0.930845022
p_ni:  0.067392516
p_wrong:  0.001762462
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
2
6
89.6
comparative body size at age 10, self-reported
1
1
1
68.3
body height
1
1
1
66.3
2
2
0
1.1
64.2
visceral adipose tissue measurement
1
1
1
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
89.6
comparative body size at age 10, self-reported
1
68.3
body height
1
66.3
0
1.1
64.2
visceral adipose tissue measurement
1
59.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WNK lysine deficient protein kinase 1
VGNC:13495
451739
Macaque
WNK lysine deficient protein kinase 1
706493
Mouse
MGI:2442092
232341
Rat
RGD:621141
116477
Dog
WNK lysine deficient protein kinase 1
VGNC:48418
477728
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WNK lysine deficient protein kinase 1
Macaque
WNK lysine deficient protein kinase 1
Mouse
Rat
Dog
WNK lysine deficient protein kinase 1
Publication Statistics
PubMed Score 396.13
PubMed score by year
PubTator Score 333.57
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title