Tbio WLS Protein wntless homolog

Protein Summary

Description

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Uniprot Accession IDs

• Q5T9L3
• B2RNT2
• Q5JRS7
• Q7Z2Z9
• Q8NC43

Gene Name

• WLS

Ensembl ID

• ENST00000262348
• ENSP00000262348
• ENSG00000116729
• ENST00000354777
• ENSP00000346829
• ENST00000370976
• ENSP00000360015

Symbol

• C1orf139
• GPR177
• EVI
• MRP
• GPR177
• mig-14
• C1orf139

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
trait	0.86
ligand (protein) perturbation	0.83
PubMedID	0.83
interacting protein	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0