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Tbio
WIZ
Protein Wiz

Protein Summary
Description
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263381
  • ENSP00000263381
  • ENSG00000011451
  • ENST00000545156
  • ENSP00000445824
  • ENST00000599686
  • ENSP00000469534

Symbol
  • ZNF803
  • ZNF803
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.94
disease perturbation
0.74
drug perturbation
0.71
kinase perturbation
0.71
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
XAGE2
Tbio
Novelty:  0.15338981
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
XAGE3
Tdark
Novelty:  0.1418603
p_int:  0.999999129
p_ni:  8.71e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
ZNF462
Tbio
Novelty:  0.13731082
p_int:  0.99999903
p_ni:  9.7e-7
Score:  0.347
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.999998217
p_ni:  0.000001783
Data Source:  BioPlex
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.999958199
p_ni:  0.000041801
Score:  0.552
Data Source:  BioPlex,STRINGDB
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
p_int:  0.999834238
p_ni:  0.00016576
p_wrong:  2e-9
Data Source:  BioPlex
L3MBTL1
Tchem
Family:  TF; Epigenetic
Novelty:  0.02321712
p_int:  0.999637786
p_ni:  0.000362214
Score:  0.304
Data Source:  BioPlex,STRINGDB
MIER2
Tbio
Novelty:  0.85226416
p_int:  0.998364356
p_ni:  0.001635644
Score:  0.226
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.959533509
p_ni:  0.040466491
Data Source:  BioPlex
ZBTB46
Tbio
Family:  TF
Novelty:  0.04699856
p_int:  0.935885485
p_ni:  0.064114515
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
4
4
80.5
red blood cell density measurement
1
1
1
72.3
reticulocyte measurement
1
1
1
44.2
mean corpuscular hemoglobin concentration
1
1
1
31.1
monocyte percentage of leukocytes
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
80.5
red blood cell density measurement
1
72.3
reticulocyte measurement
1
44.2
mean corpuscular hemoglobin concentration
1
31.1
monocyte percentage of leukocytes
1
10.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
widely interspaced zinc finger motifs
718251
Mouse
MGI:1332638
22404
Rat
RGD:1307771
314598
Dog
widely interspaced zinc finger motifs
476682
Horse
widely interspaced zinc finger motifs
100063247
Species
Name
OMA
EggNOG
Inparanoid
Macaque
widely interspaced zinc finger motifs
Mouse
Rat
Dog
widely interspaced zinc finger motifs
Horse
widely interspaced zinc finger motifs
Publication Statistics
PubMed Score 18.62
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
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PMID
Year
Title