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Tbio
WIPI2
WD repeat domain phosphoinositide-interacting protein 2

Protein Summary
Description
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. I ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288828
  • ENSP00000288828
  • ENSG00000157954
  • ENST00000382384
  • ENSP00000371821
  • ENST00000401525
  • ENSP00000384945
  • ENST00000404704
  • ENSP00000385297
  • ENST00000484262
  • ENSP00000429654

Symbol
  • Atg21
  • ATG18B
  • CGI-50
  • WIPI-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
kinase perturbation
0.93
transcription factor
0.75
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.98   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.98   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.999999989
p_ni:  1e-8
p_wrong:  1e-9
Score:  0.246
Data Source:  BioPlex,STRINGDB
ATG16L1
Tbio
Novelty:  0.0031765
p_int:  0.999997706
p_ni:  0.000002294
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
BCAS3
Tbio
Novelty:  0.0343539
p_int:  0.999994267
p_ni:  0.000005733
Score:  0.876
Data Source:  BioPlex,STRINGDB
ATG5
Tbio
Novelty:  0.00081472
p_int:  0.999991799
p_ni:  0.000003865
p_wrong:  0.000004336
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
BNIP3L
Tbio
Novelty:  0.00579795
p_int:  0.999949008
p_ni:  9.91e-7
p_wrong:  0.00005
Score:  0.506
Data Source:  BioPlex,STRINGDB
DPH2
Tbio
Novelty:  0.04268301
p_int:  0.998650698
p_ni:  0.000137905
p_wrong:  0.001211398
Score:  0.295
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.965826943
p_ni:  0.034145646
p_wrong:  0.000027411
Data Source:  BioPlex
DPH1
Tbio
Novelty:  0.02296024
p_int:  0.925867252
p_ni:  0.074132748
Score:  0.232
Data Source:  BioPlex,STRINGDB
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
p_int:  0.845666465
p_ni:  0.154333535
Score:  0.198
Data Source:  BioPlex,STRINGDB
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.785177634
p_ni:  0.014220067
p_wrong:  0.200602299
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
86.3
reticulocyte measurement
1
1
1
80.9
red blood cell density measurement
1
1
1
73.9
reticulocyte count
2
2
2
68.5
cardiac troponin T measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
86.3
reticulocyte measurement
1
80.9
red blood cell density measurement
1
73.9
reticulocyte count
2
68.5
cardiac troponin T measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain, phosphoinositide interacting 2
VGNC:8790
737922
Macaque
WD repeat domain, phosphoinositide interacting 2
702966
Mouse
MGI:1923831
74781
Rat
RGD:1359154
288498
Dog
WD repeat domain, phosphoinositide interacting 2
VGNC:48413
608721
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain, phosphoinositide interacting 2
Macaque
WD repeat domain, phosphoinositide interacting 2
Mouse
Rat
Dog
WD repeat domain, phosphoinositide interacting 2
Publication Statistics
PubMed Score 35.98
PubMed score by year
PubTator Score 14.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title