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Tbio
WIPF1
WAS/WASL-interacting protein family member 1

Protein Summary
Description
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272746
  • ENSP00000272746
  • ENSG00000115935
  • ENST00000359761
  • ENSP00000352802
  • ENST00000392546
  • ENSP00000376329
  • ENST00000392547
  • ENSP00000376330
  • ENST00000409891
  • ENSP00000386431

Symbol
  • WASPIP
  • WIP
  • WIP
  • WAS2
  • PRPL-2
  • WASPIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.88
gene perturbation
0.86
disease perturbation
0.83
cell type or tissue
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.58   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.58   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
NCK1
Tbio
Novelty:  0.00352084
p_int:  1
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999999997
p_ni:  1e-9
p_wrong:  2e-9
Score:  0.705
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999993
p_ni:  5e-9
p_wrong:  2e-9
Score:  0.787
Data Source:  BioPlex,Reactome,STRINGDB
WASL
Tbio
Novelty:  0.0029314
p_int:  0.99999906
p_ni:  2e-9
p_wrong:  9.38e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.999
Data Source:  Reactome,STRINGDB
ACTG1
Tbio
Novelty:  0.00086444
Score:  0.978
Data Source:  STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.978
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.972
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.969
Data Source:  Reactome,STRINGDB
ACTA1
Tbio
Novelty:  0.00111813
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
78.7
2
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
78.7
0
1.1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WAS/WASL interacting protein family member 1
VGNC:3877
459755
Macaque
WAS/WASL interacting protein family member 1
698446
Mouse
MGI:2178801
215280
Rat
RGD:620887
117538
Dog
WAS/WASL interacting protein family member 1
VGNC:48410
488409
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WAS/WASL interacting protein family member 1
Macaque
WAS/WASL interacting protein family member 1
Mouse
Rat
Dog
WAS/WASL interacting protein family member 1
Publication Statistics
PubMed Score 227.58
PubMed score by year
PubTator Score 72.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title