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Tbio
WHAMM
WASP homolog-associated protein with actin, membranes and microtubules

Protein Summary
Description
Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates grow ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286760
  • ENSP00000286760
  • ENSG00000156232

Symbol
  • KIAA1971
  • WHDC1
  • WHDC1
  • WHAMM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
cellular component
0.71
transcription factor binding site profile
0.65
cell type or tissue
0.62
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.18   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.18   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.999999773
p_ni:  2.18e-7
p_wrong:  9e-9
Data Source:  BioPlex
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
p_int:  0.999996241
p_ni:  1.06e-7
p_wrong:  0.000003652
Score:  0.26
Data Source:  BioPlex,STRINGDB
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.999748137
p_ni:  0.000007148
p_wrong:  0.000244716
Data Source:  BioPlex
WAS
Tbio
Novelty:  0.00087362
Score:  0.949
Data Source:  STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.862
Data Source:  STRINGDB
ARPC4
Tbio
Novelty:  0.04212335
Score:  0.748
Data Source:  STRINGDB
WASF3
Tbio
Novelty:  0.0248378
Score:  0.715
Data Source:  STRINGDB
BRK1
Tbio
Novelty:  0.02289534
Score:  0.703
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.696
Data Source:  STRINGDB
WDR73
Tbio
Novelty:  0.10253438
Score:  0.692
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
4
4
81.6
hip circumference
1
2
2
53.7
intelligence
2
2
0
5.7
45.6
high density lipoprotein cholesterol measurement
1
1
1
40.7
pro‐interleukin‐16 measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
4
81.6
hip circumference
2
53.7
intelligence
0
5.7
45.6
high density lipoprotein cholesterol measurement
1
40.7
pro‐interleukin‐16 measurement
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WAS protein homolog associated with actin, golgi membranes and microtubules
693446
Mouse
MGI:2142282
434204
Rat
RGD:1563506
293057
Dog
WAS protein homolog associated with actin, golgi membranes and microtubules
VGNC:53253
609719
Horse
WAS protein homolog associated with actin, golgi membranes and microtubules
100068345
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WAS protein homolog associated with actin, golgi membranes and microtubules
Mouse
Rat
Dog
WAS protein homolog associated with actin, golgi membranes and microtubules
Horse
WAS protein homolog associated with actin, golgi membranes and microtubules
Publication Statistics
PubMed Score 16.18
PubMed score by year
PubTator Score 8.59
PubTator score by year
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Related Publications
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PMID
Year
Title