WFDC5
WAP four-disulfide core domain protein 5
Protein Summary
Putative acid-stable proteinase inhibitor. This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]
- ENST00000307971
- ENSP00000312381
- ENSG00000175121
- ENST00000372789
- ENSP00000361875
- PRG5
- WAP1
- PRG5
- WAP1
- dJ211D12.5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.62 | ||
cell type or tissue | 0.57 | ||
cell line | 0.54 | ||
microRNA | 0.41 | ||
tissue | 0.37 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.88 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 131 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.88 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 131 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0