You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
WFDC5
WAP four-disulfide core domain protein 5

Protein Summary
Description
Putative acid-stable proteinase inhibitor. This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307971
  • ENSP00000312381
  • ENSG00000175121
  • ENST00000372789
  • ENSP00000361875

Symbol
  • PRG5
  • WAP1
  • PRG5
  • WAP1
  • dJ211D12.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.62
cell type or tissue
0.57
cell line
0.54
microRNA
0.41
tissue
0.37


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
WFDC12
Tbio
Novelty:  0.14304609
Score:  0.813
Data Source:  STRINGDB
ELF5
Tbio
Family:  TF
Novelty:  0.01490486
Score:  0.802
Data Source:  STRINGDB
GADD45GIP1
Tbio
Novelty:  0.03765684
Score:  0.741
Data Source:  STRINGDB
ADGRF4
Tdark
Family:  GPCR
Novelty:  0.20109261
Score:  0.683
Data Source:  STRINGDB
WFDC8
Tdark
Novelty:  0.3858941
Score:  0.589
Data Source:  STRINGDB
MDH2
Tchem
Family:  Enzyme
Novelty:  0.00217694
Score:  0.586
Data Source:  STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
Score:  0.58
Data Source:  STRINGDB
PDS5A
Tbio
Novelty:  0.0142948
Score:  0.563
Data Source:  STRINGDB
C5orf46
Tdark
Novelty:  0.21780536
Score:  0.549
Data Source:  STRINGDB
SEMG2
Tbio
Novelty:  0.06325799
Score:  0.547
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
94.7
feeling "fed-up" measurement
1
1
0
5.7
24.5
self reported educational attainment
1
1
1
13.4
mathematical ability
1
1
1
7.9
1
1
0
1.1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
94.7
feeling "fed-up" measurement
0
5.7
24.5
self reported educational attainment
1
13.4
mathematical ability
1
7.9
0
1.1
3.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WAP four-disulfide core domain 5
VGNC:14484
740370
Macaque
WAP four-disulfide core domain 5
711627
Mouse
MGI:2384800
209232
Rat
RGD:1304986
296352
Horse
WAP four-disulfide core domain 5
VGNC:51629
100070884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WAP four-disulfide core domain 5
Macaque
WAP four-disulfide core domain 5
Mouse
Rat
Horse
WAP four-disulfide core domain 5
Publication Statistics
PubMed Score 21.75
PubMed score by year
PubTator Score 3.27
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title