WFDC2
WAP four-disulfide core domain protein 2
Protein Summary
Broad range protease inhibitor. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
- ENST00000217425
- ENSP00000217425
- ENSG00000101443
- ENST00000339946
- ENSP00000340215
- ENST00000342873
- ENSP00000342890
- ENST00000372676
- ENSP00000361761
- HE4
- WAP5
- HE4
- WAP5
- EDDM4
- dJ461P17.6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.88 | ||
small molecule perturbation | 0.87 | ||
kinase perturbation | 0.81 | ||
gene perturbation | 0.77 | ||
biological term | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.31 (req: < 5)
Gene RIFs: 211 (req: <= 3)
Antibodies: 524 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.31 (req: >= 5)
Gene RIFs: 211 (req: > 3)
Antibodies: 524 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0