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Tbio
WFDC2
WAP four-disulfide core domain protein 2

Protein Summary
Description
Broad range protease inhibitor. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217425
  • ENSP00000217425
  • ENSG00000101443
  • ENST00000339946
  • ENSP00000340215
  • ENST00000342873
  • ENSP00000342890
  • ENST00000372676
  • ENSP00000361761

Symbol
  • HE4
  • WAP5
  • HE4
  • WAP5
  • EDDM4
  • dJ461P17.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
small molecule perturbation
0.87
kinase perturbation
0.81
gene perturbation
0.77
biological term
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.87   (req: < 5)
Gene RIFs: 146   (req: <= 3)
Antibodies: 524   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.87   (req: >= 5)
Gene RIFs: 146   (req: > 3)
Antibodies: 524   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
WDR81
Tbio
Novelty:  0.04564761
p_int:  1
Score:  0.359
Data Source:  BioPlex,STRINGDB
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.999960428
p_ni:  0.000039572
Score:  0.167
Data Source:  BioPlex,STRINGDB
WDR91
Tbio
Novelty:  0.10152634
p_int:  0.999864719
p_ni:  0.000135281
Score:  0.359
Data Source:  BioPlex,STRINGDB
CRTAC1
Tbio
Novelty:  0.09442374
p_int:  0.998417157
p_ni:  0.000982927
p_wrong:  0.000599916
Score:  0.179
Data Source:  BioPlex,STRINGDB
PTPRF
Tchem
Family:  Enzyme
Novelty:  0.01017327
p_int:  0.997424267
p_ni:  0.002575733
Score:  0.198
Data Source:  BioPlex,STRINGDB
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.945237014
p_ni:  0.043530931
p_wrong:  0.011232055
Score:  0.167
Data Source:  BioPlex,STRINGDB
EIF1AX
Tbio
Novelty:  0.01945373
p_int:  0.891409854
p_ni:  0.108590145
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
GRN
Tbio
Novelty:  0.00096395
p_int:  0.836729531
p_ni:  0.163270469
Data Source:  BioPlex
FKBP7
Tbio
Family:  Enzyme
Novelty:  0.00572565
p_int:  0.801758146
p_ni:  0.198241854
Score:  0.188
Data Source:  BioPlex,STRINGDB
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.774890807
p_ni:  0.220520885
p_wrong:  0.004588308
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
CACAO
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
15.8
free cholesterol measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
15.8
free cholesterol measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WAP four-disulfide core domain 2
VGNC:10138
458283
Macaque
WAP four-disulfide core domain 2
710469
Mouse
MGI:1914951
67701
Rat
RGD:628757
286888
Dog
WAP four-disulfide core domain 2
VGNC:54267
403919
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WAP four-disulfide core domain 2
Macaque
WAP four-disulfide core domain 2
Mouse
Rat
Dog
WAP four-disulfide core domain 2
Publication Statistics
PubMed Score 100.87
PubMed score by year
PubTator Score 439.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title