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Tbio
WDTC1
WD and tetratricopeptide repeats protein 1

Protein Summary
Description
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319394
  • ENSP00000317971
  • ENSG00000142784
  • ENST00000361771
  • ENSP00000355317
  • ENST00000447062
  • ENSP00000434578

Symbol
  • KIAA1037
  • ADP
  • DCAF9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
cell type or tissue
0.86
protein domain
0.85
biological process
0.8
small molecule perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.51   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.51   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (671)
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.999904527
p_ni:  0.000095473
Score:  0.154
Data Source:  BioPlex,STRINGDB
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.999891733
p_ni:  0.000108267
Score:  0.935
Data Source:  BioPlex,STRINGDB
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.999630925
p_ni:  0.000369075
Score:  0.183
Data Source:  BioPlex,STRINGDB
CUL4B
Tbio
Novelty:  0.0133075
p_int:  0.999613118
p_ni:  0.000386882
Score:  0.93
Data Source:  BioPlex,STRINGDB
MIPEP
Tbio
Family:  Enzyme
Novelty:  0.01507033
p_int:  0.999247863
p_ni:  0.000752137
Score:  0.165
Data Source:  BioPlex,STRINGDB
ETNK1
Tbio
Family:  Kinase
Novelty:  0.04817798
p_int:  0.998649997
p_ni:  0.001349412
p_wrong:  5.91e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
DDB1
Tbio
Novelty:  0.00345896
p_int:  0.996081967
p_ni:  0.003918033
Score:  0.987
Data Source:  BioPlex,STRINGDB
PNOC
Tbio
Novelty:  0.00132014
p_int:  0.993564426
p_ni:  0.006435573
Data Source:  BioPlex
PPP1R21
Tdark
Family:  Enzyme
Novelty:  0.33099657
p_int:  0.991055186
p_ni:  0.008939961
p_wrong:  0.000004852
Data Source:  BioPlex
SLC25A22
Tbio
Family:  Transporter
Novelty:  0.05854569
p_int:  0.98463847
p_ni:  0.01536153
Score:  0.558
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD and tetratricopeptide repeats 1
VGNC:1635
469244
Macaque
WD and tetratricopeptide repeats 1
715790
Mouse
MGI:2685541
230796
Rat
RGD:1310362
313020
Dog
WD and tetratricopeptide repeats 1
VGNC:48400
487347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD and tetratricopeptide repeats 1
Macaque
WD and tetratricopeptide repeats 1
Mouse
Rat
Dog
WD and tetratricopeptide repeats 1
Publication Statistics
PubMed Score 52.51
PubMed score by year
PubTator Score 204.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title