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Tbio
WDR83
WD repeat domain-containing protein 83

Protein Summary
Description
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418543
  • ENSP00000402653
  • ENSG00000123154

Symbol
  • MORG1
  • MORG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.72
histone modification site profile
0.69
transcription factor
0.68
cellular component
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.51   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.51   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
ZHX1
Tbio
Family:  TF
Novelty:  0.04449432
p_int:  1
Score:  0.173
Data Source:  BioPlex,STRINGDB
DCAF13
Tbio
Novelty:  0.02796363
p_int:  0.999999879
p_ni:  7.8e-8
p_wrong:  4.3e-8
Score:  0.529
Data Source:  BioPlex,STRINGDB
KIAA1671
Tdark
Novelty:  1.1816849
p_int:  0.999999833
p_ni:  1.67e-7
Data Source:  BioPlex
GPATCH1
Tdark
Novelty:  0.93318176
p_int:  0.999999794
p_ni:  1.98e-7
p_wrong:  8e-9
Score:  0.91
Data Source:  BioPlex,STRINGDB
SH2B2
Tbio
Novelty:  0.20893668
p_int:  0.999999778
p_ni:  5e-9
p_wrong:  2.17e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
GPSM1
Tbio
Novelty:  0.03510582
p_int:  0.999999766
p_ni:  1.38e-7
p_wrong:  9.6e-8
Data Source:  BioPlex
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.999999715
p_ni:  2.85e-7
p_wrong:  1e-9
Data Source:  BioPlex
RBM15B
Tbio
Novelty:  0.15620369
p_int:  0.999999457
p_ni:  5.43e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
DHX35
Tdark
Family:  Enzyme
Novelty:  0.26052594
p_int:  0.999998324
p_ni:  0.000001676
Score:  0.584
Data Source:  BioPlex,STRINGDB
KCTD3
Tdark
Novelty:  0.33599775
p_int:  0.999997807
p_ni:  0.000002193
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAP2K and MAPK activation
Reactome
MAPK family signaling cascades
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAP2K and MAPK activation
MAPK family signaling cascades
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
1
1
42.3
body height
1
1
1
24.5
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
42.3
body height
1
24.5
1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 83
716260
Mouse
MGI:1915086
67836
Rat
RGD:1306947
288924
Dog
WD repeat domain 83
VGNC:48392
484931
Horse
WD repeat domain 83
VGNC:25020
100064298
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 83
Mouse
Rat
Dog
WD repeat domain 83
Horse
WD repeat domain 83
Publication Statistics
PubMed Score 12.51
PubMed score by year
PubTator Score 4.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title