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Tbio
WDR82
WD repeat-containing protein 82

Protein Summary
Description
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296490
  • ENSP00000296490
  • ENSG00000164091

Symbol
  • TMEM113
  • WDR82A
  • SWD2
  • MST107
  • WDR82A
  • MSTP107
  • PRO2730
  • TMEM113
  • PRO34047
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.97
microRNA
0.77
protein domain
0.73
cellular component
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.14   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.14   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (184)
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.998
Data Source:  STRINGDB
SETD1B
Tbio
Family:  Epigenetic
Novelty:  0.03331663
Score:  0.997
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.997
Data Source:  STRINGDB
DPY30
Tbio
Novelty:  0.03098629
Score:  0.996
Data Source:  STRINGDB
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
Score:  0.996
Data Source:  STRINGDB
SSU72
Tbio
Family:  Enzyme
Novelty:  0.02342759
Score:  0.992
Data Source:  STRINGDB
CXXC1
Tbio
Family:  Epigenetic
Novelty:  0.01019251
Score:  0.991
Data Source:  STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
Score:  0.985
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.985
Data Source:  STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
4
5
87.6
BMI-adjusted waist-hip ratio
3
4
5
86.8
triglyceride measurement
2
3
3
86.7
BMI-adjusted waist circumference
2
4
5
86.1
urate measurement
1
2
2
80.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
5
87.6
BMI-adjusted waist-hip ratio
5
86.8
triglyceride measurement
3
86.7
BMI-adjusted waist circumference
5
86.1
urate measurement
2
80.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 82
697708
Mouse
MGI:1924555
77305
Dog
WD repeat domain 82
VGNC:48391
484740
Platypus
WD repeat domain 82
100084303
Chicken
WD repeat domain 82
CGNC:50122
415942
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 82
Mouse
Dog
WD repeat domain 82
Platypus
WD repeat domain 82
Chicken
WD repeat domain 82
Publication Statistics
PubMed Score 20.14
PubMed score by year
PubTator Score 6.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title