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Tbio
WDR81
WD repeat-containing protein 81

Protein Summary
Description
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). This gene encodes a multi-domain transmembrane protein which is predominantly expressed in the brain and is thought to play ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309182
  • ENSP00000312074
  • ENSG00000167716
  • ENST00000409644
  • ENSP00000386609
  • ENST00000419248
  • ENSP00000407845
  • ENST00000437219
  • ENSP00000391074
  • ENST00000611758
  • ENSP00000480442
  • ENSG00000276021
  • ENST00000613381
  • ENSP00000480101
  • ENST00000613616
  • ENSP00000477991

Symbol
  • HYC3
  • CAMRQ2
  • SORF-2
  • PPP1R166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.89
disease perturbation
0.74
protein domain
0.73
transcription factor binding site profile
0.73
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.27   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.27   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
WFDC2
Tbio
Novelty:  0.0136923
p_int:  1
Score:  0.359
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999937196
p_ni:  0.000012596
p_wrong:  0.000050208
Data Source:  BioPlex
WDR91
Tbio
Novelty:  0.10152634
Score:  0.948
Data Source:  STRINGDB
CA8
Tbio
Family:  Enzyme
Novelty:  0.0041859
Score:  0.903
Data Source:  STRINGDB
MAP1LC3C
Tbio
Novelty:  0.04062334
Score:  0.798
Data Source:  STRINGDB
TLCD2
Tdark
Novelty:  0.42814411
Score:  0.791
Data Source:  STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
Score:  0.764
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.723
Data Source:  STRINGDB
SMYD4
Tbio
Family:  Epigenetic
Novelty:  0.18455037
Score:  0.712
Data Source:  STRINGDB
RTN4RL1
Tbio
Novelty:  0.07113722
Score:  0.699
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
5
6
97.6
serum albumin measurement
3
5
6
97.6
sex hormone-binding globulin measurement
6
3
8
96.6
sex hormone-binding globulin measurement
6
3
8
96.6
calcium measurement
1
3
3
93.4
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
6
97.6
serum albumin measurement
6
97.6
sex hormone-binding globulin measurement
8
96.6
sex hormone-binding globulin measurement
8
96.6
calcium measurement
3
93.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 81
VGNC:10295
468136
Mouse
MGI:2681828
192652
Rat
RGD:1311334
303312
Dog
WD repeat domain 81
VGNC:48390
611263
Opossum
WD repeat domain 81
100018162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 81
Mouse
Rat
Dog
WD repeat domain 81
Opossum
WD repeat domain 81
Publication Statistics
PubMed Score 32.27
PubMed score by year
PubTator Score 16.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title