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Tbio
WDR75
WD repeat-containing protein 75

Protein Summary
Description
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314761
  • ENSP00000314193
  • ENSG00000115368

Symbol
  • UTP17
  • NET16
  • UTP17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
ligand (protein) perturbation
0.83
histone modification site profile
0.81
virus perturbation
0.79
tissue
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (322)
UTP4
Tbio
Novelty:  0.06989008
p_int:  0.999993819
p_ni:  0.00000618
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
NOL7
Tbio
Novelty:  0.24085052
p_int:  0.999986981
p_ni:  0.000013019
Score:  0.795
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.999910437
p_ni:  0.000089563
Data Source:  BioPlex
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.996376611
p_ni:  0.003623388
Data Source:  BioPlex
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.986494328
p_ni:  0.013505667
p_wrong:  5e-9
Score:  0.907
Data Source:  BioPlex,STRINGDB
C1D
Tbio
Novelty:  0.00997109
p_int:  0.985613122
p_ni:  0.014386863
p_wrong:  1.5e-8
Score:  0.916
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.974953715
p_ni:  0.025046275
p_wrong:  1e-8
Data Source:  BioPlex
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.964085077
p_ni:  0.035914879
p_wrong:  4.4e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.904185493
p_ni:  0.095814507
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
PLEK
Tbio
Novelty:  0.00074263
p_int:  0.883803403
p_ni:  0.116196583
p_wrong:  1.4e-8
Score:  0.369
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
2
2
2
92.7
neuroimaging measurement
5
5
5
74
mean corpuscular hemoglobin concentration
1
1
1
52.5
iron biomarker measurement
2
1
2
43.5
red blood cell distribution width
2
1
2
37.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
2
92.7
neuroimaging measurement
5
74
mean corpuscular hemoglobin concentration
1
52.5
iron biomarker measurement
2
43.5
red blood cell distribution width
2
37.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 75
VGNC:3876
459819
Macaque
WD repeat domain 75
709104
Mouse
MGI:1920924
73674
Rat
RGD:1564869
314545
Dog
WD repeat domain 75
VGNC:48387
488443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 75
Macaque
WD repeat domain 75
Mouse
Rat
Dog
WD repeat domain 75
Publication Statistics
PubMed Score 13.89
PubMed score by year
PubTator Score 0.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title