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Tbio
WDR62
WD repeat-containing protein 62

Protein Summary
Description
Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270301
  • ENSP00000270301
  • ENSG00000075702
  • ENST00000401500
  • ENSP00000384792
  • ENST00000587391
  • ENSP00000465525

Symbol
  • C19orf14
  • MCPH2
  • C19orf14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
histone modification site profile
0.84
drug perturbation
0.71
tissue
0.65
small molecule perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.52   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.52   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
p_int:  0.99999563
p_ni:  0.00000437
Score:  0.84
Data Source:  BioPlex,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.992843709
p_ni:  0.007156291
Score:  0.475
Data Source:  BioPlex,STRINGDB
A1BG
Tbio
Novelty:  0.00508743
p_int:  0.98555863
p_ni:  0.01444137
Score:  0.189
Data Source:  BioPlex,STRINGDB
KIF2B
Tbio
Novelty:  0.09958244
p_int:  0.98513999
p_ni:  0.01486001
Score:  0.154
Data Source:  BioPlex,STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.92050049
p_ni:  0.07949951
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.893065886
p_ni:  0.106934114
Data Source:  BioPlex
ZBBX
Tdark
Novelty:  1.66474399
p_int:  0.875392074
p_ni:  0.124607926
Data Source:  BioPlex
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.851152297
p_ni:  0.148847703
Data Source:  BioPlex
TENT5A
Tbio
Novelty:  0.08412895
p_int:  0.771498327
p_ni:  0.228501673
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.770956382
p_ni:  0.229043618
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.5
neutrophil percentage of leukocytes
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.5
neutrophil percentage of leukocytes
1
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923696
233064
Rat
RGD:1306714
308492
Dog
WD repeat domain 62
VGNC:48380
484565
Horse
WD repeat domain 62
VGNC:25009
100060345
Cow
WD repeat domain 62
VGNC:36910
530449
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
WD repeat domain 62
Horse
WD repeat domain 62
Cow
WD repeat domain 62
Publication Statistics
PubMed Score 58.52
PubMed score by year
PubTator Score 35.33
PubTator score by year
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Related Publications
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PMID
Year
Title