Tbio WDR6 WD repeat-containing protein 6

Protein Summary

Description

Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q9NNW5
• B4DHK2
• Q3MIT1
• Q9UF63

Gene Name

• WDR6

Ensembl ID

• ENST00000608424
• ENSP00000477389
• ENSG00000178252

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
interacting protein	0.89
histone modification site profile	0.86
transcription factor binding site profile	0.7
kinase perturbation	0.6

Protein Classes

DTO Classes

Wd Repeat-containing Protein 63 / Wd Repeat-containing Protein 60

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.01   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.01   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0