You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
WDR59
GATOR complex protein WDR59

Protein Summary
Description
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262144
  • ENSP00000262144
  • ENSG00000103091
  • ENST00000616369
  • ENSP00000482446

Symbol
  • KIAA1923
  • CDW12
  • FP977
  • p90-120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.72
tissue sample
0.65
tissue
0.62
transcription factor binding site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.01   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.01   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
GRB10
Tbio
Novelty:  0.00762794
p_int:  0.999999999
p_ni:  1e-9
Score:  0.277
Data Source:  BioPlex,STRINGDB
HDLBP
Tbio
Novelty:  0.00979636
p_int:  0.999999125
p_ni:  8.75e-7
Data Source:  BioPlex
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.999983662
p_ni:  0.000016338
Score:  0.996
Data Source:  BioPlex,STRINGDB
NRF1
Tbio
Family:  TF
Novelty:  0.00543248
p_int:  0.999948777
p_ni:  5.3e-8
p_wrong:  0.00005117
Score:  0.297
Data Source:  BioPlex,STRINGDB
UEVLD
Tdark
Novelty:  0.60010918
p_int:  0.999936849
p_ni:  3.25e-7
p_wrong:  0.000062826
Score:  0.332
Data Source:  BioPlex,STRINGDB
PITHD1
Tdark
Novelty:  0.32046117
p_int:  0.999619518
p_ni:  0.000380482
Score:  0.212
Data Source:  BioPlex,STRINGDB
EPB41L2
Tbio
Novelty:  0.0311733
p_int:  0.996858474
p_ni:  0.003141526
Data Source:  BioPlex
NUP54
Tbio
Novelty:  0.08155008
p_int:  0.996604752
p_ni:  0.003395248
Score:  0.195
Data Source:  BioPlex,STRINGDB
CASTOR1
Tbio
Novelty:  0.10145237
p_int:  0.984240527
p_ni:  0.015759473
Score:  0.694
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.983721239
p_ni:  0.01627876
Score:  0.248
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 59
VGNC:5954
454244
Macaque
WD repeat domain 59
710576
Mouse
MGI:2442115
319481
Rat
RGD:1592213
690751
Dog
WD repeat domain 59
VGNC:48376
479653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 59
Macaque
WD repeat domain 59
Mouse
Rat
Dog
WD repeat domain 59
Publication Statistics
PubMed Score 3.01
PubMed score by year
PubTator Score 0.88
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title