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Tdark
WDR54
WD repeat-containing protein 54

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348227
  • ENSP00000006526
  • ENSG00000005448
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.74
cell line
0.65
tissue sample
0.6
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.11   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.11   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
OSCP1
Tbio
Novelty:  0.05361924
p_int:  0.999999982
p_ni:  1.2e-8
p_wrong:  5e-9
Score:  0.768
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999119794
p_ni:  0.000880206
Data Source:  BioPlex
FLYWCH2
Tdark
Novelty:  1.44186144
p_int:  0.996565476
p_ni:  0.003434524
Score:  0.167
Data Source:  BioPlex,STRINGDB
MEMO1
Tbio
Novelty:  0.0506558
p_int:  0.989470644
p_ni:  0.010529356
Score:  0.196
Data Source:  BioPlex,STRINGDB
GYG2
Tbio
Family:  Enzyme
Novelty:  0.01520991
p_int:  0.984870945
p_ni:  0.015129041
p_wrong:  1.5e-8
Score:  0.288
Data Source:  BioPlex,STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.983223797
p_ni:  0.016776201
p_wrong:  1e-9
Data Source:  BioPlex
GMEB1
Tbio
Family:  TF
Novelty:  0.10522678
p_int:  0.981781944
p_ni:  0.018218056
Score:  0.179
Data Source:  BioPlex,STRINGDB
STAC3
Tbio
Novelty:  0.03431498
p_int:  0.972943036
p_ni:  0.027056964
Score:  0.252
Data Source:  BioPlex,STRINGDB
APEX2
Tbio
Family:  Enzyme
Novelty:  0.04076395
p_int:  0.972556527
p_ni:  0.027443473
Score:  0.179
Data Source:  BioPlex,STRINGDB
USP16
Tbio
Family:  Enzyme
Novelty:  0.13211126
p_int:  0.966142329
p_ni:  0.033857671
Score:  0.165
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
1
2
57.9
platelet crit
1
1
1
48.8
appendicular lean mass
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
57.9
platelet crit
1
48.8
appendicular lean mass
1
5.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 54
VGNC:421
459333
Macaque
WD repeat domain 54
708605
Mouse
MGI:1922909
75659
Rat
RGD:1561494
500226
Dog
WD repeat domain 54
VGNC:48375
475789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 54
Macaque
WD repeat domain 54
Mouse
Rat
Dog
WD repeat domain 54
Publication Statistics
PubMed Score 2.11
PubMed score by year
PubTator Score 0.67
PubTator score by year
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Related Publications
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PMID
Year
Title