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Tbio
WDR45B
WD repeat domain phosphoinositide-interacting protein 3

Protein Summary
Description
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735). This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome cont ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392325
  • ENSP00000376139
  • ENSG00000141580

Symbol
  • WDR45L
  • WIPI3
  • WIPI3
  • WDR45L
  • WIPI-3
  • NEDSBAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.78
transcription factor binding site profile
0.75
interacting protein
0.7
histone modification site profile
0.68
transcription factor
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
KHDRBS2
Tbio
Novelty:  0.01986638
p_int:  0.999894904
p_ni:  0.000105096
Data Source:  BioPlex
KCNJ5
Tchem
Family:  IC
Novelty:  0.00385775
p_int:  0.999817204
p_ni:  0.000182796
Data Source:  BioPlex
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.999551075
p_ni:  0.000448925
Data Source:  BioPlex
ASPRV1
Tbio
Family:  Enzyme
Novelty:  0.0278626
p_int:  0.999413362
p_ni:  0.000586637
Score:  0.158
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999051861
p_ni:  0.000948139
Data Source:  BioPlex
GAS2L1
Tbio
Novelty:  0.17484834
p_int:  0.997290261
p_ni:  0.002709739
Data Source:  BioPlex
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
p_int:  0.997189081
p_ni:  0.002810919
Score:  0.167
Data Source:  BioPlex,STRINGDB
TFAP4
Tbio
Family:  TF
Novelty:  0.03155887
p_int:  0.992125181
p_ni:  0.007874819
Data Source:  BioPlex
MT1F
Tbio
Novelty:  0.03838808
p_int:  0.989588686
p_ni:  0.010411313
Data Source:  BioPlex
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.989321537
p_ni:  0.010678462
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
13
13
18
99.6
red blood cell distribution width
4
2
5
91.5
reticulocyte count
4
3
4
87.5
heel bone mineral density
2
2
2
85.5
mean corpuscular hemoglobin concentration
1
1
1
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
18
99.6
red blood cell distribution width
5
91.5
reticulocyte count
4
87.5
heel bone mineral density
2
85.5
mean corpuscular hemoglobin concentration
1
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 45B
VGNC:9784
745537
Macaque
WD repeat domain 45B
719616
Mouse
MGI:1914090
66840
Rat
RGD:1305141
360682
Dog
WD repeat domain 45B [Source:HGNC Symbol;Acc:HGNC:25072]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 45B
Macaque
WD repeat domain 45B
Mouse
Rat
Dog
WD repeat domain 45B [Source:HGNC Symbol;Acc:HGNC:25072]
Publication Statistics
PubMed Score 6.83
PubMed score by year
PubTator Score 1.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title