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Tbio
WDR45
WD repeat domain phosphoinositide-interacting protein 4

Protein Summary
Description
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066). This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322995
  • ENSP00000365543
  • ENSG00000196998
  • ENST00000356463
  • ENSP00000348848
  • ENST00000376368
  • ENSP00000365546
  • ENST00000376372
  • ENSP00000365551
  • ENST00000634944
  • ENSP00000488972

Symbol
  • WDRX1
  • WDRXI4
  • WIPI4
  • JM5
  • NBIA4
  • NBIA5
  • WDRX1
  • WIPI4
  • WIPI-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
0.98
histone modification site profile
0.91
transcription factor
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.94   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.94   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0