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Tbio
WDR37
WD repeat-containing protein 37

Protein Summary
Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263150
  • ENSP00000263150
  • ENSG00000047056
  • ENST00000358220
  • ENSP00000350954

Symbol
  • KIAA0982
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.9
kinase perturbation
0.88
virus perturbation
0.85
histone modification site profile
0.79
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
PACS1
Tbio
Novelty:  0.02030091
p_int:  0.999999966
p_ni:  2.1e-8
p_wrong:  1.2e-8
Score:  0.888
Data Source:  BioPlex,STRINGDB
LRRC46
Tdark
Novelty:  1.159245
p_int:  0.999999615
p_ni:  3.84e-7
Score:  0.223
Data Source:  BioPlex,STRINGDB
PACS2
Tbio
Novelty:  0.00887813
p_int:  0.999999484
p_ni:  3.75e-7
p_wrong:  1.41e-7
Score:  0.904
Data Source:  BioPlex,STRINGDB
LEAP2
Tbio
Novelty:  0.01484908
p_int:  0.999996364
p_ni:  0.000003636
Data Source:  BioPlex
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.997771968
p_ni:  0.000941501
p_wrong:  0.001286531
Score:  0.327
Data Source:  BioPlex,STRINGDB
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.996987423
p_ni:  0.000715689
p_wrong:  0.002296889
Data Source:  BioPlex
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.996747686
p_ni:  0.003252314
Score:  0.185
Data Source:  BioPlex,STRINGDB
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.996398104
p_ni:  0.002859808
p_wrong:  0.000742088
Data Source:  BioPlex
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.964450134
p_ni:  0.031907804
p_wrong:  0.003642062
Data Source:  BioPlex
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
p_int:  0.922332707
p_ni:  0.077667159
p_wrong:  1.34e-7
Score:  0.274
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
3
4
93.3
glomerular filtration rate
3
3
4
93.1
testosterone measurement
1
1
1
64.9
serum urea measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
4
93.3
glomerular filtration rate
4
93.1
testosterone measurement
1
64.9
serum urea measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 37
VGNC:5882
465999
Macaque
WD repeat domain 37
709975
Mouse
MGI:1920393
207615
Rat
RGD:1306189
307075
Dog
WD repeat domain 37
VGNC:48364
607652
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 37
Macaque
WD repeat domain 37
Mouse
Rat
Dog
WD repeat domain 37
Publication Statistics
PubMed Score 6.74
PubMed score by year
PubTator Score 0.38
PubTator score by year
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Related Publications
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PMID
Year
Title