Tbio WDR35 WD repeat-containing protein 35

Protein Summary

Description

As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport, it is involved in ciliogenesis (PubMed:21473986, PubMed:28400947). May promote CASP3 activation and TNF-stimulated apoptosis. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9P2L0
• B3KVI5
• Q4ZG01
• Q8NE11

Gene Name

• WDR35

Ensembl ID

• ENST00000281405
• ENSP00000281405
• ENSG00000118965
• ENST00000345530
• ENSP00000314444

Symbol

• IFT121
• KIAA1336
• CED2
• IFTA1
• SRTD7
• IFT121

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
cell type or tissue	0.64
phenotype	0.64
tissue sample	0.62
cellular component	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.41   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 56   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.41   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0