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Tbio
WDR34
WD repeat-containing protein 34

Protein Summary
Description
Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372715
  • ENSP00000361800
  • ENSG00000119333

Symbol
  • DIC5
  • FAP133
  • SRTD11
  • bA216B9.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.86
cell type or tissue
0.63
transcription factor
0.62
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.03   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.03   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
TCTEX1D2
Tbio
Novelty:  0.15075459
p_int:  0.999852596
p_ni:  0.000147404
Score:  0.98
Data Source:  BioPlex,STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
p_int:  0.996383076
p_ni:  0.003616924
Score:  0.755
Data Source:  BioPlex,STRINGDB
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.992755403
p_ni:  0.003079769
p_wrong:  0.004164828
Data Source:  BioPlex
TCTEX1D4
Tbio
Novelty:  1.11393549
p_int:  0.96596189
p_ni:  0.03403811
Score:  0.48
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.963963446
p_ni:  0.03603649
p_wrong:  6.4e-8
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.953945652
p_ni:  0.046054348
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.933648576
p_ni:  0.066351424
Score:  0.531
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.920216435
p_ni:  0.079783565
Data Source:  BioPlex
TBC1D31
Tdark
Novelty:  0.87979858
p_int:  0.91328735
p_ni:  0.086709194
p_wrong:  0.000003456
Score:  0.308
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.905745687
p_ni:  0.094254313
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
91.9
platelet crit
2
2
2
89.4
sex hormone-binding globulin measurement
6
1
6
83.3
platelet count
1
1
1
71.6
neutrophil count
2
1
2
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
91.9
platelet crit
2
89.4
sex hormone-binding globulin measurement
6
83.3
platelet count
1
71.6
neutrophil count
2
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 34
VGNC:4903
464772
Macaque
WD repeat domain 34
722609
Mouse
MGI:1919070
71820
Rat
RGD:1359465
296618
Dog
WD repeat domain 34
VGNC:48361
491314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 34
Macaque
WD repeat domain 34
Mouse
Rat
Dog
WD repeat domain 34
Publication Statistics
PubMed Score 21.03
PubMed score by year
PubTator Score 8.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title