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Tdark
WDR27
WD repeat-containing protein 27

Protein Summary
Description
This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423258
  • ENSP00000397869
  • ENSG00000184465
  • ENST00000448612
  • ENSP00000416289
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor binding site profile
0.77
tissue sample
0.7
transcription factor perturbation
0.61
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.803420923
p_ni:  0.196579077
Score:  0.267
Data Source:  BioPlex,STRINGDB
PHF10
Tbio
Family:  Epigenetic
Novelty:  0.05941323
Score:  0.825
Data Source:  STRINGDB
BBS10
Tbio
Novelty:  0.03343798
Score:  0.791
Data Source:  STRINGDB
TCTE3
Tdark
Novelty:  0.15747856
Score:  0.756
Data Source:  STRINGDB
CXorf56
Tdark
Novelty:  0.39137617
Score:  0.718
Data Source:  STRINGDB
C6orf120
Tdark
Novelty:  0.90888293
Score:  0.708
Data Source:  STRINGDB
LRRC23
Tdark
Novelty:  0.67210911
Score:  0.69
Data Source:  STRINGDB
PDXDC1
Tbio
Family:  Enzyme
Novelty:  0.16529476
Score:  0.689
Data Source:  STRINGDB
WRB
Tbio
Novelty:  0.01267171
Score:  0.672
Data Source:  STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
Score:  0.672
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
55.8
1
1
0
5.6
50.7
educational attainment
1
1
1
48
neutrophil count
1
1
1
44.7
insomnia measurement
1
1
0
1.1
42
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
55.8
0
5.6
50.7
educational attainment
1
48
neutrophil count
1
44.7
insomnia measurement
0
1.1
42
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 27
695097
Mouse
MGI:1918932
71682
Rat
RGD:1309633
308222
Dog
WD repeat domain 27
612528
Horse
WD repeat domain 27
VGNC:49371
100053367
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 27
Mouse
Rat
Dog
WD repeat domain 27
Horse
WD repeat domain 27
Publication Statistics
PubMed Score 1.07
PubMed score by year
PubTator Score 0.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title