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Tdark
WDR25
WD repeat-containing protein 25

Protein Summary
Description
This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335290
  • ENSP00000334148
  • ENSG00000176473
  • ENST00000402312
  • ENSP00000385540
  • ENST00000542471
  • ENSP00000441903
  • ENST00000554998
  • ENSP00000450661

Symbol
  • C14orf67
  • C14orf67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
histone modification site profile
0.69
tissue sample
0.65
small molecule perturbation
0.61
cell line
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.48   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.48   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.999998481
p_ni:  5.86e-7
p_wrong:  9.34e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999996329
p_ni:  0.000003357
p_wrong:  3.14e-7
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999993765
p_ni:  0.000006235
Score:  0.221
Data Source:  BioPlex,STRINGDB
XAB2
Tbio
Novelty:  0.04104647
Score:  0.892
Data Source:  STRINGDB
SLU7
Tbio
Novelty:  0.0366131
Score:  0.88
Data Source:  STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
Score:  0.876
Data Source:  STRINGDB
DHX16
Tbio
Family:  Enzyme
Novelty:  0.02678951
Score:  0.874
Data Source:  STRINGDB
DHX38
Tbio
Family:  Enzyme
Novelty:  0.01939445
Score:  0.874
Data Source:  STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
Score:  0.867
Data Source:  STRINGDB
SYF2
Tbio
Novelty:  0.06114903
Score:  0.867
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
90.9
age at menarche
3
3
2
2.3
78.5
testosterone measurement
3
3
3
74
apolipoprotein A 1 measurement
1
1
1
59.9
glucose measurement
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
90.9
age at menarche
2
2.3
78.5
testosterone measurement
3
74
apolipoprotein A 1 measurement
1
59.9
glucose measurement
1
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 25
VGNC:12421
743142
Macaque
WD repeat-containing protein 25
717667
Mouse
MGI:3045255
212198
Rat
RGD:1562505
314443
Dog
WD repeat domain 25
VGNC:48357
490858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 25
Macaque
WD repeat-containing protein 25
Mouse
Rat
Dog
WD repeat domain 25
Publication Statistics
PubMed Score 1.48
PubMed score by year
PubTator Score 0.70
PubTator score by year
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Related Publications
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PMID
Year
Title