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Tdark
WDR24
GATOR complex protein WDR24

Protein Summary
Description
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248142
  • ENSP00000248142
  • ENSG00000127580
  • ENST00000293883
  • ENSP00000293883

Symbol
  • C16orf21
  • JFP7
  • C16orf21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.71
tissue sample
0.71
transcription factor
0.68
transcription factor binding site profile
0.63
histone modification site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999999873
p_ni:  1.27e-7
Data Source:  BioPlex
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.999999172
p_ni:  8.28e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CASTOR1
Tbio
Novelty:  0.10145237
p_int:  0.99999158
p_ni:  0.00000842
Score:  0.782
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999943505
p_ni:  0.000048492
p_wrong:  0.000008003
Data Source:  BioPlex
NPRL2
Tbio
Family:  Enzyme
Novelty:  0.02848752
Score:  0.999
Data Source:  STRINGDB
WDR59
Tdark
Novelty:  0.22243351
Score:  0.999
Data Source:  STRINGDB
DEPDC5
Tbio
Novelty:  0.0177511
Score:  0.999
Data Source:  STRINGDB
MIOS
Tdark
Novelty:  0.04252507
Score:  0.999
Data Source:  STRINGDB
NPRL3
Tbio
Family:  Enzyme
Novelty:  0.0110744
Score:  0.999
Data Source:  STRINGDB
SEH1L
Tbio
Novelty:  0.03666501
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
9
10
91.7
BMI-adjusted waist circumference
1
7
7
82.8
cancer antigen 125 measurement
1
3
3
77.9
mean corpuscular volume
1
1
1
74.6
smoking status measurement
2
1
2
70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
91.7
BMI-adjusted waist circumference
7
82.8
cancer antigen 125 measurement
3
77.9
mean corpuscular volume
1
74.6
smoking status measurement
2
70
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 24
VGNC:51236
749852
Macaque
WD repeat domain 24
697343
Mouse
MGI:2446285
268933
Rat
RGD:1304803
360497
Dog
WD repeat domain 24
VGNC:48356
479891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 24
Macaque
WD repeat domain 24
Mouse
Rat
Dog
WD repeat domain 24
Publication Statistics
PubMed Score 1.23
PubMed score by year
PubTator Score 0.78
PubTator score by year
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Related Publications
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PMID
Year
Title