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Tdark
WDR17
WD repeat-containing protein 17

Protein Summary
Description
This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280190
  • ENSP00000280190
  • ENSG00000150627
  • ENST00000508596
  • ENSP00000422763
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.73
tissue sample
0.64
cell type or tissue
0.59
cell line
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.04   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.04   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999999994
p_ni:  6e-9
Data Source:  BioPlex
PRR35
Tdark
Novelty:  3.65395394
Score:  0.785
Data Source:  STRINGDB
SPCS3
Tbio
Family:  Enzyme
Novelty:  0.13677259
Score:  0.695
Data Source:  STRINGDB
NCOR2
Tchem
Family:  TF
Novelty:  0.00066449
Score:  0.671
Data Source:  STRINGDB
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.671
Data Source:  STRINGDB
ASB5
Tdark
Novelty:  0.33891683
Score:  0.631
Data Source:  STRINGDB
CEP44
Tdark
Novelty:  1.20621472
Score:  0.627
Data Source:  STRINGDB
SPATA4
Tbio
Novelty:  0.11011458
Score:  0.597
Data Source:  STRINGDB
GPM6A
Tbio
Novelty:  0.04123799
Score:  0.577
Data Source:  STRINGDB
IMPG1
Tbio
Novelty:  0.03770903
Score:  0.571
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
63.7
cognitive function measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
63.7
cognitive function measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 17
VGNC:708
471356
Mouse
MGI:1924662
244484
Dog
WD repeat domain 17
VGNC:48353
482934
Horse
WD repeat domain 17
VGNC:24983
100146539
Cow
WD repeat domain 17
VGNC:36884
783416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 17
Mouse
Dog
WD repeat domain 17
Horse
WD repeat domain 17
Cow
WD repeat domain 17
Publication Statistics
PubMed Score 2.04
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title