You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
WDR13
WD repeat-containing protein 13

Protein Summary
Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218056
  • ENSP00000218056
  • ENSG00000101940
  • ENST00000376729
  • ENSP00000365919

Symbol
  • MG21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.8
transcription factor
0.67
histone modification site profile
0.66
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.87   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.87   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
B3GAT3
Tbio
Family:  Enzyme
Novelty:  0.0289834
p_int:  0.999992422
p_ni:  0.000005244
p_wrong:  0.000002335
Score:  0.261
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999973179
p_ni:  0.000001948
p_wrong:  0.000024873
Score:  0.2
Data Source:  BioPlex,STRINGDB
BBS10
Tbio
Novelty:  0.03343798
Score:  0.733
Data Source:  STRINGDB
AKIRIN1
Tbio
Novelty:  0.16318877
Score:  0.712
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.664
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.653
Data Source:  STRINGDB
RAB44
Tdark
Family:  Enzyme
Novelty:  0.16987153
Score:  0.634
Data Source:  STRINGDB
FNDC3A
Tbio
Novelty:  0.04721453
Score:  0.581
Data Source:  STRINGDB
THOC2
Tbio
Novelty:  0.02886456
Score:  0.56
Data Source:  STRINGDB
WDR33
Tbio
Novelty:  0.09221439
Score:  0.552
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 13
VGNC:1186
449584
Mouse
MGI:1914661
73447
Dog
WD repeat domain 13
VGNC:48352
480904
Horse
WD repeat domain 13 [Source:HGNC Symbol;Acc:HGNC:14352]
Cow
WD repeat domain 13
VGNC:36883
523881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 13
Mouse
Dog
WD repeat domain 13
Horse
WD repeat domain 13 [Source:HGNC Symbol;Acc:HGNC:14352]
Cow
WD repeat domain 13
Publication Statistics
PubMed Score 21.87
PubMed score by year
PubTator Score 5.69
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title