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Tbio
WDPCP
WD repeat-containing and planar cell polarity effector protein fritz homolog

Protein Summary
Description
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272321
  • ENSP00000272321
  • ENSG00000143951
  • ENST00000398544
  • ENSP00000381552
  • ENST00000409562
  • ENSP00000387222

Symbol
  • BBS15
  • C2orf86
  • FRITZ
  • FRTZ
  • BBS15
  • FRITZ
  • CHDTHP
  • C2orf86
  • CPLANE5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
cellular component
0.72
cell type or tissue
0.68
biological process
0.66
transcription factor binding site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.68   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.68   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0