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Tbio
WDPCP
WD repeat-containing and planar cell polarity effector protein fritz homolog

Protein Summary
Description
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272321
  • ENSP00000272321
  • ENSG00000143951
  • ENST00000398544
  • ENSP00000381552
  • ENST00000409562
  • ENSP00000387222

Symbol
  • BBS15
  • C2orf86
  • FRITZ
  • FRTZ
  • BBS15
  • FRITZ
  • CHDTHP
  • C2orf86
  • CPLANE5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
cellular component
0.72
cell type or tissue
0.68
biological process
0.66
transcription factor binding site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.68   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.68   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
INTU
Tbio
Novelty:  0.02714388
Score:  0.891
Data Source:  STRINGDB
FUZ
Tbio
Novelty:  0.03001976
Score:  0.765
Data Source:  STRINGDB
TBC1D32
Tbio
Novelty:  0.25744084
Score:  0.759
Data Source:  STRINGDB
TTC25
Tdark
Novelty:  0.23064129
Score:  0.735
Data Source:  STRINGDB
SDCCAG8
Tbio
Novelty:  0.0431837
Score:  0.684
Data Source:  STRINGDB
MKS1
Tbio
Novelty:  0.02463305
Score:  0.679
Data Source:  STRINGDB
BBS12
Tbio
Novelty:  0.06131428
Score:  0.678
Data Source:  STRINGDB
TTC8
Tbio
Novelty:  0.08520636
Score:  0.674
Data Source:  STRINGDB
BBS10
Tbio
Novelty:  0.03343798
Score:  0.669
Data Source:  STRINGDB
SEPT2
Tbio
Novelty:  0.01047916
Score:  0.661
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
3
3
3
93.1
4
2
0
1.1
91.1
mathematical ability
3
3
3
86.7
neuroticism measurement
3
4
3
5.6
84.1
alcohol consumption measurement
4
2
4
83.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
3
93.1
0
1.1
91.1
mathematical ability
3
86.7
neuroticism measurement
3
5.6
84.1
alcohol consumption measurement
4
83.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat containing planar cell polarity effector
VGNC:411
459270
Macaque
WD repeat containing planar cell polarity effector
694431
Mouse
MGI:2144467
216560
Rat
RGD:1309501
305552
Dog
WD repeat containing planar cell polarity effector
VGNC:48348
474613
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat containing planar cell polarity effector
Macaque
WD repeat containing planar cell polarity effector
Mouse
Rat
Dog
WD repeat containing planar cell polarity effector
Publication Statistics
PubMed Score 18.68
PubMed score by year
PubTator Score 13.06
PubTator score by year
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Related Publications
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PMID
Year
Title