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Tbio
WDFY3
WD repeat and FYVE domain-containing protein 3

Protein Summary
Description
Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295888
  • ENSP00000295888
  • ENSG00000163625

Symbol
  • KIAA0993
  • ALFY
  • BCHS
  • MCPH18
  • ZFYVE25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
interacting protein
0.98
kinase perturbation
0.96
histone modification site profile
0.86
transcription factor
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.57   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.57   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
FLCN
Tbio
Novelty:  0.0022007
p_int:  0.999998606
p_ni:  0.000001394
Score:  0.185
Data Source:  BioPlex,STRINGDB
DEF8
Tdark
Novelty:  0.21146806
p_int:  0.999987246
p_ni:  0.000012754
p_wrong:  1e-9
Score:  0.29
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.999945892
p_ni:  0.000054108
Score:  0.476
Data Source:  BioPlex,STRINGDB
DCAF6
Tbio
Novelty:  0.01269552
p_int:  0.999398018
p_ni:  0.000601982
Score:  0.232
Data Source:  BioPlex,STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
p_int:  0.998909639
p_ni:  0.001056403
p_wrong:  0.000033957
Score:  0.598
Data Source:  BioPlex,STRINGDB
P01889
Tbio
Novelty:  0.00790207
p_int:  0.995062969
p_ni:  0.004937031
Score:  0.722
Data Source:  BioPlex,STRINGDB
ICAM1
Tchem
Novelty:  0.00009746
p_int:  0.989554129
p_ni:  0.010445865
p_wrong:  6e-9
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.982077159
p_ni:  0.017922545
p_wrong:  2.96e-7
Score:  0.266
Data Source:  BioPlex,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.98158044
p_ni:  0.018344568
p_wrong:  0.000074992
Data Source:  BioPlex
RHOT2
Tbio
Family:  Enzyme
Novelty:  0.01712732
p_int:  0.965687524
p_ni:  0.034312476
Score:  0.246
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat and FYVE domain containing 3
VGNC:710
461201
Macaque
WD repeat and FYVE domain containing 3
706535
Mouse
MGI:1096875
72145
Rat
RGD:1307097
305164
Dog
WD repeat and FYVE domain containing 3
VGNC:48346
487841
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat and FYVE domain containing 3
Macaque
WD repeat and FYVE domain containing 3
Mouse
Rat
Dog
WD repeat and FYVE domain containing 3
Publication Statistics
PubMed Score 68.57
PubMed score by year
PubTator Score 14.63
PubTator score by year
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Related Publications
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PMID
Year
Title