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Tbio
WDFY2
WD repeat and FYVE domain-containing protein 2

Protein Summary
Description
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553). This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298125
  • ENSP00000298125
  • ENSG00000139668

Symbol
  • WDF2
  • ZFYVE22
  • PROF
  • WDF2
  • ZFYVE22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor binding site profile
0.93
cell type or tissue
0.79
disease
0.71
microRNA
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.56   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.56   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
DAP3
Tbio
Novelty:  0.05551866
p_int:  0.999999805
p_ni:  1.95e-7
Score:  0.208
Data Source:  BioPlex,STRINGDB
PNOC
Tbio
Novelty:  0.00132014
p_int:  0.99999949
p_ni:  4.46e-7
p_wrong:  6.4e-8
Data Source:  BioPlex
UTP6
Tbio
Novelty:  0.06525007
p_int:  0.999998942
p_ni:  0.000001058
Score:  0.264
Data Source:  BioPlex,STRINGDB
DNTTIP1
Tbio
Family:  Enzyme
Novelty:  0.1659073
p_int:  0.99998584
p_ni:  0.000013961
p_wrong:  1.99e-7
Score:  0.202
Data Source:  BioPlex,STRINGDB
PALLD
Tbio
Novelty:  0.01191944
p_int:  0.999982074
p_ni:  0.000017924
p_wrong:  2e-9
Score:  0.202
Data Source:  BioPlex,STRINGDB
GPD2
Tbio
Family:  Enzyme
Novelty:  0.00951917
p_int:  0.999917304
p_ni:  0.000082696
Data Source:  BioPlex
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.999857634
p_ni:  0.000142365
p_wrong:  1e-9
Data Source:  BioPlex
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.999670445
p_ni:  0.000329555
Data Source:  BioPlex
SLC7A3
Tbio
Family:  Transporter
Novelty:  0.00779949
p_int:  0.999648921
p_ni:  0.000351078
p_wrong:  1e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
RUFY1
Tbio
Novelty:  0.16796947
p_int:  0.999263933
p_ni:  0.000736067
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
Name
Explore in Pharos
Explore in Source
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
59.8
leukocyte count
1
1
1
49.5
heel bone mineral density
2
1
2
47.7
lysophosphatidylethanolamine measurement
1
1
1
24.5
cognitive decline measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
59.8
leukocyte count
1
49.5
heel bone mineral density
2
47.7
lysophosphatidylethanolamine measurement
1
24.5
cognitive decline measurement
1
15.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat and FYVE domain containing 2
VGNC:13157
452730
Macaque
WD repeat and FYVE domain containing 2
708929
Mouse
MGI:2442811
268752
Rat
RGD:1307337
305956
Dog
WD repeat and FYVE domain containing 2
VGNC:54388
606922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat and FYVE domain containing 2
Macaque
WD repeat and FYVE domain containing 2
Mouse
Rat
Dog
WD repeat and FYVE domain containing 2
Publication Statistics
PubMed Score 52.56
PubMed score by year
PubTator Score 2.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title