Tbio WBP4 WW domain-binding protein 4

Protein Summary

Description

Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75554
• B7Z4M2
• Q32P29
• WBP-4

Gene Name

• WBP4

Ensembl ID

• ENST00000379487
• ENSP00000368801
• ENSG00000120688

Symbol

• FBP21
• FNBP21
• FBP21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
kinase perturbation	0.99
transcription factor binding site profile	0.91
disease perturbation	0.87
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.7   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.7   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (210)

Explore Interacting Targets

1 – 10 of 210

• See Interactions on String-DB

RBM45

Tbio

Novelty:  0.06739873

p_int:  0.999995893

p_ni:  0.000004107

Score:  0.187

Data Source:  BioPlex,STRINGDB

SNRPF

Tdark

Novelty:  0.17624854

p_int:  0.999959074

p_ni:  0.000040926

Score:  0.985

Data Source:  BioPlex,STRINGDB

SNRPN

Tbio

Novelty:  0.002157

p_int:  0.999066995

p_ni:  0.000933005

Score:  0.941

Data Source:  BioPlex,STRINGDB

LSM6

Tbio

Novelty:  0.09507671

p_int:  0.998595827

p_ni:  0.001404173

Score:  0.995

Data Source:  BioPlex,STRINGDB

SNRPB

Tbio

Novelty:  0.01503535

p_int:  0.997869738

p_ni:  0.001529701

p_wrong:  0.000600561

Score:  0.994

Data Source:  BioPlex,STRINGDB

LSM7

Tbio

Novelty:  0.09112723

p_int:  0.95167291

p_ni:  0.035170261

p_wrong:  0.013156829

Score:  0.979

Data Source:  BioPlex,STRINGDB

FSTL5

Tbio

Novelty:  0.09979909

p_int:  0.933846233

p_ni:  0.008024079

p_wrong:  0.058129688

Score:  0.485

Data Source:  BioPlex,STRINGDB

PRPF31

Tbio

Novelty:  0.0105753

p_int:  0.888555151

p_ni:  0.111444849

Score:  0.998

Data Source:  BioPlex,STRINGDB

SNRPB2

Tbio

Novelty:  0.17219587

Score:  0.996

Data Source:  STRINGDB

SNRNP200

Tchem

Family:  Enzyme

Novelty:  0.01339666

Score:  0.994

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Metabolism of RNA (R-HSA-8953854)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (3)

Components (4)

Processes (2)

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1 – 3 of 3

GO Term	Evidence	Assigned by
proline-rich region binding	Inferred from Physical Interaction (IPI)	UniProtKB
nucleic acid binding	Inferred from Electronic Annotation (IEA)	InterPro
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (19)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		78.6
lymphocyte count	EFO_0004587	2	1	2		78
alkaline phosphatase measurement	EFO_0004533	1	1	1		76.5
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		74.8
platelet crit	EFO_0007985	1	1	1		71.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 19

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte percentage of leukocytes	EFO_0007993	1		78.6
lymphocyte count	EFO_0004587	2		78
alkaline phosphatase measurement	EFO_0004533	1		76.5
neutrophil percentage of leukocytes	EFO_0007990	1		74.8
platelet crit	EFO_0007985	1		71.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Metal-binding
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein A 1 measurement
aspartate aminotransferase measurement
body height
Crohn's disease
eosinophil percentage of leukocytes
high density lipoprotein cholesterol measurement
intraocular pressure measurement
lymphocyte count
lymphocyte percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	WW domain binding protein 4	VGNC:14522	452706
Macaque	WW domain binding protein 4		698220
Mouse	WW domain binding protein 4	MGI:109568	22380
Rat	WW domain binding protein 4	RGD:620033	114765
Dog	WW domain binding protein 4	VGNC:48343	476935

Species	Name	OMA	EggNOG	Inparanoid
Chimp	WW domain binding protein 4
Macaque	WW domain binding protein 4
Mouse	WW domain binding protein 4
Rat	WW domain binding protein 4
Dog	WW domain binding protein 4

Publication Statistics

PubMed Score 11.70

PubMed score by year

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PubTator Score 5.50

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (4)

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PMID	Year	Title