Tbio WBP4 WW domain-binding protein 4

Protein Summary

Description

Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75554
• B7Z4M2
• Q32P29
• WBP-4

Gene Name

• WBP4

Ensembl ID

• ENST00000379487
• ENSP00000368801
• ENSG00000120688

Symbol

• FBP21
• FNBP21
• FBP21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
kinase perturbation	0.99
transcription factor binding site profile	0.91
disease perturbation	0.87
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.43   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.43   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0