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Tbio
WBP1
WW domain-binding protein 1

Protein Summary
Description
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233615
  • ENSP00000233615
  • ENSG00000239779

Symbol
  • WBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.66
transcription factor binding site profile
0.66
tissue sample
0.62
transcription factor
0.59
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.89   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.89   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.999982703
p_ni:  0.000017297
Score:  0.384
Data Source:  BioPlex,STRINGDB
WWOX
Tbio
Family:  Enzyme
Novelty:  0.00335243
p_int:  0.999974143
p_ni:  0.000025857
Score:  0.424
Data Source:  BioPlex,STRINGDB
HECW2
Tbio
Family:  Enzyme
Novelty:  0.07194044
p_int:  0.999940254
p_ni:  0.000059746
Score:  0.177
Data Source:  BioPlex,STRINGDB
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.999825475
p_ni:  0.000174516
p_wrong:  9e-9
Data Source:  BioPlex
KCNIP2
Tbio
Family:  IC
Novelty:  0.01123517
p_int:  0.999801234
p_ni:  0.000198746
p_wrong:  1.9e-8
Score:  0.278
Data Source:  BioPlex,STRINGDB
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.998932649
p_ni:  0.001067351
Score:  0.568
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.998913076
p_ni:  0.001086889
p_wrong:  3.5e-8
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.995382763
p_ni:  0.004617237
Data Source:  BioPlex
SLC39A11
Tbio
Family:  Transporter
Novelty:  0.09770302
p_int:  0.994522626
p_ni:  0.005477374
p_wrong:  1e-9
Data Source:  BioPlex
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
p_int:  0.990179755
p_ni:  0.009820245
Score:  0.361
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
64.9
body height
1
1
1
59.9
platelet crit
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
64.9
body height
1
59.9
platelet crit
1
59
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WW domain binding protein 1
709202
Mouse
MGI:104710
22377
Rat
RGD:1304961
297381
Dog
WW domain binding protein 1
VGNC:48338
475787
Horse
WW domain binding protein 1
VGNC:24970
100630257
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WW domain binding protein 1
Mouse
Rat
Dog
WW domain binding protein 1
Horse
WW domain binding protein 1
Publication Statistics
PubMed Score 0.89
PubMed score by year
PubTator Score 7.79
PubTator score by year
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Related Publications
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PMID
Year
Title