Protein Summary
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093).
- ENST00000240079
- ENSP00000240079
- ENSG00000120860
- CCDC53
- CGI-116
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.78 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 43 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.78 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 43 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (91)
WASHC2A
Novelty: 1.4430096
p_int: 0.999999998
p_ni: 2e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
WASHC4
Novelty: 0.05930527
p_int: 0.999999997
p_ni: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MGAT4A
Family: Enzyme
Novelty: 0.05868941
p_int: 0.999999995
p_ni: 5e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
WASHC2C
Novelty: 0.09738237
p_int: 0.999999993
p_ni: 2e-9
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
WASHC5
Novelty: 0.02909884
p_int: 0.999999989
p_ni: 8e-9
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
HSBP1
Novelty: 0.09422832
p_int: 0.999999973
p_ni: 2.4e-8
p_wrong: 2e-9
Score: 0.91
Data Source: BioPlex,STRINGDB
WASHC1
Novelty: 0.09242196
p_int: 0.999999723
p_ni: 2.77e-7
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 3 | 3 | 3 | 97.3 | |||||
IGF-1 measurement | 1 | 3 | 3 | 95 | |||||
brain stem volume measurement | 1 | 1 | 0 | 10.7 | 78 | ||||
central corneal thickness | 1 | 1 | 0 | 2.4 | 64.4 | ||||
BMI-adjusted hip circumference | 2 | 2 | 3 | 60.1 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 3 | 97.3 | |||||
IGF-1 measurement | 3 | 95 | |||||
brain stem volume measurement | 0 | 10.7 | 78 | ||||
central corneal thickness | 0 | 2.4 | 64.4 | ||||
BMI-adjusted hip circumference | 3 | 60.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | WASH complex subunit 3 | VGNC:5319 | 740826 | |||||
Mouse | MGI:1914532 | 67282 | ||||||
Rat | RGD:1563761 | 299707 | ||||||
Dog | WASH complex subunit 3 | 475444 | ||||||
Horse | WASH complex subunit 3 | VGNC:24967 | 100053117 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | WASH complex subunit 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | WASH complex subunit 3 | |||||
Horse | WASH complex subunit 3 | |||||
Publication Statistics
PubMed Score 3.78
PubMed score by year
PubTator Score 1.63
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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