Tdark WASHC3 WASH complex subunit 3

Protein Summary

Description

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093).

Uniprot Accession IDs

• Q9Y3C0
• B2RC74
• Q53FF0
• Q6IAI4
• Q96QK0

Gene Name

• WASHC3

Ensembl ID

• ENST00000240079
• ENSP00000240079
• ENSG00000120860

Symbol

• CCDC53
• CGI-116

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.1   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 43   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.1   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0