Protein Summary
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093).
- ENST00000240079
- ENSP00000240079
- ENSG00000120860
- CCDC53
- CGI-116
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.78 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 43 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.78 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 43 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (91)
WASHC2A
Novelty: 1.4430096
p_int: 0.999999998
p_ni: 2e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
WASHC4
Novelty: 0.05930527
p_int: 0.999999997
p_ni: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MGAT4A
Family: Enzyme
Novelty: 0.05868941
p_int: 0.999999995
p_ni: 5e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
WASHC2C
Novelty: 0.09738237
p_int: 0.999999993
p_ni: 2e-9
p_wrong: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
WASHC5
Novelty: 0.02909884
p_int: 0.999999989
p_ni: 8e-9
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
HSBP1
Novelty: 0.09422832
p_int: 0.999999973
p_ni: 2.4e-8
p_wrong: 2e-9
Score: 0.91
Data Source: BioPlex,STRINGDB
WASHC1
Novelty: 0.09242196
p_int: 0.999999723
p_ni: 2.77e-7
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 3 | 3 | 3 | 97.3 | |||||
IGF-1 measurement | 1 | 3 | 3 | 95 | |||||
brain stem volume measurement | 1 | 1 | 0 | 10.7 | 78 | ||||
central corneal thickness | 1 | 1 | 0 | 2.4 | 64.4 | ||||
BMI-adjusted hip circumference | 2 | 2 | 3 | 60.1 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 3 | 97.3 | |||||
IGF-1 measurement | 3 | 95 | |||||
brain stem volume measurement | 0 | 10.7 | 78 | ||||
central corneal thickness | 0 | 2.4 | 64.4 | ||||
BMI-adjusted hip circumference | 3 | 60.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | WASH complex subunit 3 | VGNC:5319 | 740826 | |||||
Mouse | MGI:1914532 | 67282 | ||||||
Rat | RGD:1563761 | 299707 | ||||||
Dog | WASH complex subunit 3 | 475444 | ||||||
Horse | WASH complex subunit 3 | VGNC:24967 | 100053117 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | WASH complex subunit 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | WASH complex subunit 3 | |||||
Horse | WASH complex subunit 3 | |||||
Publication Statistics
PubMed Score 3.78
PubMed score by year
PubTator Score 1.63
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
|---|