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Tbio
WASHC1
WASH complex subunit 1

Protein Summary
Description
Acts as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting (PubMed:20498093). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442898
  • ENSP00000485627
  • ENSG00000181404

Symbol
  • FAM39E
  • WASH1
  • WASH
  • WASH1
  • FAM39E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.19   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.19   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
WASHC2C
Tbio
Novelty:  0.09738237
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
WASHC2A
Tdark
Novelty:  1.4430096
p_int:  0.999999997
p_wrong:  3e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
WASH2P
Tdark
Novelty:  2.49106532
p_int:  0.999999995
p_wrong:  5e-9
Score:  0.72
Data Source:  BioPlex,STRINGDB
WASHC4
Tdark
Novelty:  0.05930527
p_int:  0.999999993
p_ni:  7e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
WASH4P
Tdark
Novelty:  3.55555556
p_int:  0.999999983
p_wrong:  1.7e-8
Score:  0.728
Data Source:  BioPlex,STRINGDB
WASHC5
Tbio
Novelty:  0.02909884
p_int:  0.99999998
p_ni:  2e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999999723
p_ni:  2.77e-7
p_wrong:  1e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.999998668
p_ni:  0.000001047
p_wrong:  2.85e-7
Data Source:  BioPlex
STK40
Tbio
Family:  Kinase
Novelty:  0.10461675
p_int:  0.999997046
p_ni:  0.000002952
p_wrong:  2e-9
Data Source:  BioPlex
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.999987845
p_ni:  0.000012153
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
67.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
WAS protein family homolog 1
533602
Species
Name
OMA
EggNOG
Inparanoid
Cow
WAS protein family homolog 1
Publication Statistics
PubMed Score 10.19
PubMed score by year
PubTator Score 2.27
PubTator score by year
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Related Publications
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PMID
Year
Title