Tbio WASF3 Wiskott-Aldrich syndrome protein family member 3

Protein Summary

Description

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q9UPY6
• O94974
• Q86VQ2
• WASP family protein member 3

Gene Name

• WASF3

Ensembl ID

• ENST00000335327
• ENSP00000335055
• ENSG00000132970
• ENST00000361042
• ENSP00000354325

Symbol

• KIAA0900
• SCAR3
• WAVE3
• SCAR3
• WAVE3
• Brush-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
tissue sample	0.76
transcription factor	0.67
kinase perturbation	0.66
microRNA	0.62

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Wiskott-aldrich Syndrome Protein Family Member 3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Wiskott-aldrich Syndrome Protein Family Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.77   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 196   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.77   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (103)

Explore Interacting Targets

1 – 10 of 103

• See Interactions on String-DB

ABI2

Tbio

Novelty:  0.02324355

p_int:  1

Score:  0.989

Data Source:  BioPlex,STRINGDB

TIMM50

Tbio

Family:  Enzyme

Novelty:  0.0238053

p_int:  0.999926949

p_ni:  0.000072847

p_wrong:  2.04e-7

Score:  0.708

Data Source:  BioPlex,STRINGDB

NCK2

Tbio

Novelty:  0.02220251

p_int:  0.999871155

p_ni:  0.000122469

p_wrong:  0.000006376

Score:  0.671

Data Source:  BioPlex,STRINGDB

ABI1

Tbio

Novelty:  0.00796638

p_int:  0.999782665

p_ni:  0.000217323

p_wrong:  1.1e-8

Score:  0.99

Data Source:  BioPlex,STRINGDB

NCKAP1

Tbio

Novelty:  0.03486454

p_int:  0.999606081

p_ni:  0.00039392

Score:  0.997

Data Source:  BioPlex,STRINGDB

GTF2IRD1

Tbio

Family:  TF

Novelty:  0.01858027

p_int:  0.998761347

p_ni:  0.001238628

p_wrong:  2.5e-8

Score:  0.181

Data Source:  BioPlex,STRINGDB

BRK1

Tbio

Novelty:  0.02289534

p_int:  0.998204449

p_ni:  0.001739202

p_wrong:  0.000056349

Score:  0.998

Data Source:  BioPlex,STRINGDB

CMTR1

Tbio

Family:  Enzyme

Novelty:  0.09259694

p_int:  0.990119422

p_ni:  0.009880578

Score:  0.205

Data Source:  BioPlex,STRINGDB

CYFIP2

Tbio

Novelty:  0.01910939

p_int:  0.98970798

p_ni:  0.01029202

Score:  0.993

Data Source:  BioPlex,STRINGDB

HOXB9

Tbio

Family:  TF

Novelty:  0.01591519

p_int:  0.973373147

p_ni:  0.026183857

p_wrong:  0.000442996

Score:  0.185

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (2)

1 – 2 of 2

LYN

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  1

1: Fc gamma R-mediated phagocytosis

HCK

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  1

1: Fc gamma R-mediated phagocytosis

Pathways (14)

Reactome (11)

KEGG (3)

Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

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5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Fcgamma receptor (FCGR) dependent phagocytosis	163 targets	R-HSA-2029480
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	RHO GTPase Effectors	273 targets	R-HSA-195258
Reactome	RHO GTPases Activate WASPs and WAVEs	36 targets	R-HSA-5663213

Name	Explore in Pharos	Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis	163 targets	R-HSA-2029480
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
RHO GTPase Effectors	273 targets	R-HSA-195258
RHO GTPases Activate WASPs and WAVEs	36 targets	R-HSA-5663213

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (1)

Components (6)

Processes (8)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	1	1	1		9
alcohol consumption measurement	EFO_0007878	2	1	2		6.2
systolic blood pressure	EFO_0006335	1	1	1		4.5
body height	EFO_0004339	1	1	1		3.2
mathematical ability	EFO_0004875	1	1	1		1.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	1		9
alcohol consumption measurement	EFO_0007878	2		6.2
systolic blood pressure	EFO_0006335	1		4.5
body height	EFO_0004339	1		3.2
mathematical ability	EFO_0004875	1		1.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
appendicular lean mass
body height
mathematical ability
systolic blood pressure

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	WAS protein family member 3	VGNC:5133	452502
Macaque	WAS protein family member 3		709849
Mouse	WAS protein family, member 3	MGI:2658986	245880
Dog	WAS protein family member 3	VGNC:48335	477331
Horse	WAS protein family member 3	VGNC:24966	100050895

Species	Name	OMA	EggNOG	Inparanoid
Chimp	WAS protein family member 3
Macaque	WAS protein family member 3
Mouse	WAS protein family, member 3
Dog	WAS protein family member 3
Horse	WAS protein family member 3

Publication Statistics

PubMed Score 56.77

PubMed score by year

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PubTator Score 211.89

PubTator score by year

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Related Publications

Text Mined References (46)

GeneRif Annotations (33)

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PMID	Year	Title