Protein Summary
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
- ENST00000261405
- ENSP00000261405
- ENSG00000110799
- F8VWF
- VWD
- F8VWF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
viral protein | 1 | ||
PubMedID | 0.95 | ||
protein domain | 0.92 | ||
cellular component | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11847.07 (req: < 5)
Gene RIFs: 715 (req: <= 3)
Antibodies: 1819 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11847.07 (req: >= 5)
Gene RIFs: 715 (req: > 3)
Antibodies: 1819 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (425)
Nearest Tclin Targets
Pathways (45)
Reactome (31)
KEGG (6)
PathwayCommons (2)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
FLT3 Signaling | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (9)
Components (7)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 8 | 10 | 99.6 | |||||
platelet count | 3 | 5 | 4 | 2.5 | 95.8 | ||||
von Willebrand factor measurement | 2 | 2 | 2 | 1.8 | 94.8 | ||||
factor VIII measurement | 2 | 3 | 3 | 2.6 | 90.8 | ||||
coagulation factor measurement | 1 | 1 | 1 | 65.9 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 10 | 99.6 | |||||
platelet count | 4 | 2.5 | 95.8 | ||||
von Willebrand factor measurement | 2 | 1.8 | 94.8 | ||||
factor VIII measurement | 3 | 2.6 | 90.8 | ||||
coagulation factor measurement | 1 | 65.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | von Willebrand factor | VGNC:5646 | 451773 | |||||
Mouse | MGI:98941 | 22371 | ||||||
Dog | von Willebrand factor | VGNC:48329 | 399544 | |||||
Horse | von Willebrand factor | VGNC:24961 | 100059472 | |||||
Opossum | von Willebrand factor | 100014453 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | von Willebrand factor | |||||
Mouse | ||||||
Dog | von Willebrand factor | |||||
Horse | von Willebrand factor | |||||
Opossum | von Willebrand factor | |||||
Publication Statistics
PubMed Score 11847.07
PubMed score by year
PubTator Score 5685.76
PubTator score by year
Related Publications
Text Mined References (847)
GeneRif Annotations (715)
Items per page:
0 of 0
PMID | Year | Title |
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