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Tdark
VWDE
von Willebrand factor D and EGF domain-containing protein

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275358
  • ENSP00000275358
  • ENSG00000146530
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
histone modification site profile
0.65
tissue sample
0.64
cell line
0.63
PubMedID
0.51


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.999989699
p_ni:  0.000010301
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.999940362
p_ni:  0.000059638
Data Source:  BioPlex
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.999809743
p_ni:  0.000189468
p_wrong:  7.89e-7
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.999751952
p_ni:  0.000248048
Data Source:  BioPlex
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.999344366
p_ni:  0.000655341
p_wrong:  2.94e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.999144231
p_ni:  0.000853677
p_wrong:  0.000002093
Data Source:  BioPlex
FAM19A5
Tdark
Novelty:  0.07792418
p_int:  0.998470714
p_ni:  0.001527832
p_wrong:  0.000001454
Data Source:  BioPlex
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.998029976
p_ni:  0.00195841
p_wrong:  0.000011614
Data Source:  BioPlex
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.997705708
p_ni:  0.002283438
p_wrong:  0.000010854
Data Source:  BioPlex
CCL26
Tbio
Novelty:  0.00556498
p_int:  0.997431863
p_ni:  0.002323621
p_wrong:  0.000244517
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
3
91.9
blood protein measurement
1
1
1
73.4
aging
2
1
0
5.5
64.2
brain measurement
2
1
0
5.5
64.2
wellbeing measurement
1
1
1
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
91.9
blood protein measurement
1
73.4
aging
0
5.5
64.2
brain measurement
0
5.5
64.2
wellbeing measurement
1
58.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor D and EGF domains
VGNC:4562
463267
Mouse
MGI:2685313
232585
Dog
von Willebrand factor D and EGF domains
VGNC:48328
482323
Pig
von Willebrand factor D and EGF domains
100512803
Xenopus
von Willebrand factor D and EGF domains
XB-GENE-1217528
100495432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor D and EGF domains
Mouse
Dog
von Willebrand factor D and EGF domains
Pig
von Willebrand factor D and EGF domains
Xenopus
von Willebrand factor D and EGF domains
Publication Statistics
PubMed Score 4.95
PubMed score by year
PubTator Score 0.04
PubTator score by year
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Related Publications
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PMID
Year
Title