You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
VWCE
von Willebrand factor C and EGF domain-containing protein

Protein Summary
Description
May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301770
  • ENSP00000301770
  • ENSG00000167992
  • ENST00000335613
  • ENSP00000334186

Symbol
  • URG11
  • VWC1
  • URG11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue sample
0.6
cell line
0.58
histone modification site profile
0.51
tissue
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.999999964
p_ni:  3.6e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
ZNF444
Tdark
Family:  TF
Novelty:  0.21564163
p_int:  0.999999412
p_ni:  5.88e-7
Data Source:  BioPlex
ZNF747
Tdark
Novelty:  9
p_int:  0.999999053
p_ni:  6.88e-7
p_wrong:  2.59e-7
Data Source:  BioPlex
ZNF669
Tdark
Family:  TF
Novelty:  2.09725685
p_int:  0.999998488
p_ni:  6.7e-7
p_wrong:  8.43e-7
Data Source:  BioPlex
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  0.999998336
p_ni:  0.000001487
p_wrong:  1.77e-7
Data Source:  BioPlex
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.99999815
p_ni:  0.000001849
Data Source:  BioPlex
ZNF664
Tdark
Family:  TF
Novelty:  0.25879878
p_int:  0.999997602
p_ni:  0.000001815
p_wrong:  5.82e-7
Data Source:  BioPlex
ITFG2
Tbio
Novelty:  0.41720651
p_int:  0.999996635
p_ni:  0.000003365
Data Source:  BioPlex
ZNF627
Tdark
Family:  TF
Novelty:  0.34605017
p_int:  0.999995557
p_ni:  0.000003906
p_wrong:  5.37e-7
Data Source:  BioPlex
ZNF620
Tdark
Family:  TF
Novelty:  2.57179565
p_int:  0.999995107
p_ni:  0.000001326
p_wrong:  0.000003567
Score:  0.166
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
12.4
serum albumin measurement
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
12.4
serum albumin measurement
1
6.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor C and EGF domains
VGNC:940
451233
Macaque
von Willebrand factor C and EGF domains
694385
Mouse
MGI:1919018
71768
Rat
RGD:1309910
309209
Dog
von Willebrand factor C and EGF domains
VGNC:48327
483801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor C and EGF domains
Macaque
von Willebrand factor C and EGF domains
Mouse
Rat
Dog
von Willebrand factor C and EGF domains
Publication Statistics
PubMed Score 14.26
PubMed score by year
PubTator Score 8.43
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title