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Tdark
VWC2L
von Willebrand factor C domain-containing protein 2-like

Protein Summary
Description
May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312504
  • ENSP00000308976
  • ENSG00000174453
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.53
disease
0.53
gene perturbation
0.53
phenotype
0.48
transcription factor
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.48   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.48   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
SHISA6
Tdark
Novelty:  0.34379596
Score:  0.785
Data Source:  STRINGDB
WDR60
Tbio
Novelty:  0.13020561
Score:  0.698
Data Source:  STRINGDB
SHISA9
Tbio
Novelty:  0.10986428
Score:  0.689
Data Source:  STRINGDB
SKIDA1
Tdark
Novelty:  0.28113063
Score:  0.688
Data Source:  STRINGDB
ESYT2
Tbio
Novelty:  0.04545794
Score:  0.686
Data Source:  STRINGDB
CPAMD8
Tbio
Novelty:  0.05558484
Score:  0.678
Data Source:  STRINGDB
BARD1
Tbio
Novelty:  0.00513841
Score:  0.677
Data Source:  STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
Score:  0.649
Data Source:  STRINGDB
PORCN
Tchem
Family:  Enzyme
Novelty:  0.00834643
Score:  0.623
Data Source:  STRINGDB
ARL15
Tbio
Family:  Enzyme
Novelty:  0.09327102
Score:  0.61
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
3
3
80.7
mathematical ability
2
2
2
68
household income
1
2
2
63.3
neuroticism measurement
5
5
3
5.8
52.4
cognitive function measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
80.7
mathematical ability
2
68
household income
2
63.3
neuroticism measurement
3
5.8
52.4
cognitive function measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor C domain containing protein 2 like
470636
Macaque
von Willebrand factor C domain containing protein 2 like
694511
Mouse
MGI:2444069
320460
Rat
RGD:1565501
501160
Dog
von Willebrand factor C domain containing protein 2 like
VGNC:48326
488512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor C domain containing protein 2 like
Macaque
von Willebrand factor C domain containing protein 2 like
Mouse
Rat
Dog
von Willebrand factor C domain containing protein 2 like
Publication Statistics
PubMed Score 0.48
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
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PMID
Year
Title