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Tdark
VWA8
von Willebrand factor A domain-containing protein 8

Protein Summary
Description
Exhibits ATPase activity in vitro.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281496
  • ENSP00000281496
  • ENSG00000102763
  • ENST00000379310
  • ENSP00000368612

Symbol
  • KIAA0564
  • P7BP2
  • KIAA0564
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
molecular function
0.9
histone modification site profile
0.87
disease perturbation
0.83
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.04   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.04   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.999972195
p_ni:  0.000027805
Score:  0.721
Data Source:  BioPlex,STRINGDB
BMP7
Tbio
Novelty:  0.00049424
p_int:  0.999732646
p_ni:  0.000267354
Score:  0.518
Data Source:  BioPlex,STRINGDB
KERA
Tbio
Novelty:  0.00789599
p_int:  0.999536841
p_ni:  0.000463159
Score:  0.537
Data Source:  BioPlex,STRINGDB
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.999028418
p_ni:  0.000971582
Data Source:  BioPlex
PARP16
Tchem
Family:  Enzyme
Novelty:  0.09651799
p_int:  0.998337726
p_ni:  0.001662274
Score:  0.169
Data Source:  BioPlex,STRINGDB
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.995603214
p_ni:  0.004396786
Score:  0.151
Data Source:  BioPlex,STRINGDB
HSPB8
Tbio
Novelty:  0.00298618
p_int:  0.987013261
p_ni:  0.012986739
Score:  0.392
Data Source:  BioPlex,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.959430161
p_ni:  0.040569838
Data Source:  BioPlex
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.945329366
p_ni:  0.054670634
Score:  0.212
Data Source:  BioPlex,STRINGDB
LOX
Tchem
Family:  Enzyme
Novelty:  0.000273
p_int:  0.931853641
p_ni:  0.068146359
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
78.2
reticulocyte count
2
2
2
77.6
heel bone mineral density
2
2
2
61.3
chronotype measurement
1
1
1
42.3
self reported educational attainment
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
78.2
reticulocyte count
2
77.6
heel bone mineral density
2
61.3
chronotype measurement
1
42.3
self reported educational attainment
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor A domain containing 8
VGNC:10494
452560
Macaque
von Willebrand factor A domain containing 8
699086
Mouse
MGI:1919008
219189
Dog
von Willebrand factor A domain containing 8
VGNC:48325
485463
Horse
von Willebrand factor A domain containing 8
VGNC:24958
100060926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor A domain containing 8
Macaque
von Willebrand factor A domain containing 8
Mouse
Dog
von Willebrand factor A domain containing 8
Horse
von Willebrand factor A domain containing 8
Publication Statistics
PubMed Score 9.04
PubMed score by year
PubTator Score 1.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title