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Tbio
VWA5A
von Willebrand factor A domain-containing protein 5A

Protein Summary
Description
May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361352
  • ENSP00000355070
  • ENSG00000110002
  • ENST00000392748
  • ENSP00000376504
  • ENST00000449321
  • ENSP00000404683
  • ENST00000456829
  • ENSP00000407726

Symbol
  • BCSC1
  • LOH11CR2A
  • BCSC1
  • BCSC-1
  • LOH11CR2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.8
histone modification site profile
0.78
kinase perturbation
0.76
small molecule perturbation
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
MCM9
Tbio
Family:  Enzyme
Novelty:  0.0390791
p_int:  0.999983665
p_ni:  0.000016333
p_wrong:  2e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
CREBZF
Tbio
Family:  TF
Novelty:  0.06925638
p_int:  0.999965666
p_ni:  0.000015622
p_wrong:  0.000018712
Score:  0.189
Data Source:  BioPlex,STRINGDB
MAN2C1
Tbio
Family:  Enzyme
Novelty:  0.01159051
p_int:  0.999837954
p_ni:  0.0001616
p_wrong:  4.45e-7
Score:  0.21
Data Source:  BioPlex,STRINGDB
PKNOX2
Tbio
Family:  TF
Novelty:  0.02053794
p_int:  0.999817803
p_ni:  2.87e-7
p_wrong:  0.000181911
Score:  0.208
Data Source:  BioPlex,STRINGDB
PBX3
Tbio
Family:  TF
Novelty:  0.01516183
p_int:  0.999340858
p_ni:  0.000632144
p_wrong:  0.000026998
Score:  0.214
Data Source:  BioPlex,STRINGDB
ARMCX3
Tdark
Novelty:  0.25544824
p_int:  0.999255505
p_ni:  0.000744495
Data Source:  BioPlex
HIC2
Tbio
Family:  TF
Novelty:  0.1544738
p_int:  0.999212526
p_ni:  0.000787474
Data Source:  BioPlex
PTPN23
Tbio
Family:  Enzyme
Novelty:  0.03578001
p_int:  0.998204227
p_ni:  0.001794617
p_wrong:  0.000001155
Score:  0.164
Data Source:  BioPlex,STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
p_int:  0.99806611
p_ni:  0.00193389
Score:  0.275
Data Source:  BioPlex,STRINGDB
ADD3
Tbio
Family:  Enzyme
Novelty:  0.02164464
p_int:  0.9962841
p_ni:  0.0037159
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
5.6
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
5.6
4.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor A domain containing 5A
VGNC:941
451634
Macaque
von Willebrand factor A domain containing 5A
710024
Mouse
MGI:1915026
67776
Rat
RGD:735145
301097
Dog
von Willebrand factor A domain containing 5A
VGNC:48322
489335
Species
Name
OMA
EggNOG
Inparanoid
Chimp
von Willebrand factor A domain containing 5A
Macaque
von Willebrand factor A domain containing 5A
Mouse
Rat
Dog
von Willebrand factor A domain containing 5A
Publication Statistics
PubMed Score 12.21
PubMed score by year
PubTator Score 9.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title