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Tbio
VWA2
von Willebrand factor A domain-containing protein 2

Protein Summary
Description
This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392982
  • ENSP00000376708
  • ENSG00000165816
  • ENST00000603594
  • ENSP00000473752

Symbol
  • AMACO
  • AMACO
  • CCSP2
  • NET42
  • CCSP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
PubMedID
0.57
tissue sample
0.52
cell line
0.49
cell type or tissue
0.48


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.96   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.96   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
TCTEX1D2
Tbio
Novelty:  0.15075459
p_int:  0.999193671
p_ni:  0.00004613
p_wrong:  0.0007602
Score:  0.203
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.995485145
p_ni:  0.004514855
Score:  0.224
Data Source:  BioPlex,STRINGDB
KLF15
Tbio
Family:  TF
Novelty:  0.009709
p_int:  0.994392347
p_ni:  0.005607643
p_wrong:  1.1e-8
Score:  0.269
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.961488997
p_ni:  0.038511003
Data Source:  BioPlex
WDR47
Tdark
Novelty:  0.51632776
p_int:  0.933761195
p_ni:  0.066084918
p_wrong:  0.000153887
Score:  0.239
Data Source:  BioPlex,STRINGDB
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.841105174
p_ni:  0.158894826
Score:  0.553
Data Source:  BioPlex,STRINGDB
NHLRC2
Tbio
Novelty:  0.18676651
Score:  0.757
Data Source:  STRINGDB
FREM2
Tbio
Novelty:  0.03382033
Score:  0.733
Data Source:  STRINGDB
FRAS1
Tbio
Novelty:  0.02114063
Score:  0.688
Data Source:  STRINGDB
FREM3
Tdark
Novelty:  0.16573809
Score:  0.601
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
3
3
86.1
lymphocyte count
2
2
2
62.3
type 1 diabetes mellitus
1
1
0
1.3
54.8
mean corpuscular volume
1
1
1
18.4
monocyte count
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
86.1
lymphocyte count
2
62.3
type 1 diabetes mellitus
0
1.3
54.8
mean corpuscular volume
1
18.4
monocyte count
1
9.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
von Willebrand factor A domain containing 2
698261
Mouse
MGI:2684334
240675
Rat
RGD:1562000
307988
Dog
von Willebrand factor A domain containing 2
VGNC:48319
477827
Horse
von Willebrand factor A domain containing 2
VGNC:24951
100068127
Species
Name
OMA
EggNOG
Inparanoid
Macaque
von Willebrand factor A domain containing 2
Mouse
Rat
Dog
von Willebrand factor A domain containing 2
Horse
von Willebrand factor A domain containing 2
Publication Statistics
PubMed Score 39.96
PubMed score by year
PubTator Score 5.50
PubTator score by year
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Related Publications
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PMID
Year
Title